Dendrites contribute to the gradient of intrinsic timescales encompassing cortical and subcortical brain networks

IF 4.2 3区 医学 Q2 NEUROSCIENCES Frontiers in Cellular Neuroscience Pub Date : 2024-09-06 DOI:10.3389/fncel.2024.1404605
Kaichao Wu, Leonardo L. Gollo
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Abstract

IntroductionCytoarchitectonic studies have uncovered a correlation between higher levels of cortical hierarchy and reduced dendritic size. This hierarchical organization extends to the brain's timescales, revealing longer intrinsic timescales at higher hierarchical levels. However, estimating the contribution of single-neuron dendritic morphology to the hierarchy of timescales, which is typically characterized at a macroscopic level, remains challenging.MethodHere we mapped the intrinsic timescales of six functional networks using functional magnetic resonance imaging (fMRI) data, and characterized the influence of neuronal dendritic size on intrinsic timescales of brain regions, utilizing a multicompartmental neuronal modeling approach based on digitally reconstructed neurons.ResultsThe fMRI results revealed a hierarchy of intrinsic timescales encompassing both cortical and subcortical brain regions. The neuronal modeling indicated that neurons with larger dendritic structures exhibit shorter intrinsic timescales. Together these findings highlight the contribution of dendrites at the neuronal level to the hierarchy of intrinsic timescales at the whole-brain level.DiscussionThis study sheds light on the intricate relationship between neuronal structure, cytoarchitectonic maps, and the hierarchy of timescales in the brain.
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树突有助于形成涵盖皮层和皮层下大脑网络的内在时间尺度梯度
导言:晶体结构研究发现,大脑皮层层次结构越高,树突大小越小。这种分级组织延伸到大脑的时间尺度,揭示了在较高的分级水平上较长的内在时间尺度。然而,估算单神经元树突形态对时间尺度层次结构的贡献仍然具有挑战性,因为单神经元树突形态通常是在宏观水平上表征的。方法在此,我们利用功能磁共振成像(fMRI)数据绘制了六个功能网络的内在时标,并利用基于数字重建神经元的多室神经元建模方法描述了神经元树突大小对脑区内在时标的影响。神经元建模表明,具有较大树突结构的神经元表现出较短的固有时标。本研究揭示了神经元结构、细胞架构图和大脑时标层次之间错综复杂的关系。
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来源期刊
CiteScore
7.90
自引率
3.80%
发文量
627
审稿时长
6-12 weeks
期刊介绍: Frontiers in Cellular Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the cellular mechanisms underlying cell function in the nervous system across all species. Specialty Chief Editors Egidio D‘Angelo at the University of Pavia and Christian Hansel at the University of Chicago are supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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