Synaptic Vesicle Glycoprotein 2C: a role in Parkinson’s disease

IF 4.2 3区 医学 Q2 NEUROSCIENCES Frontiers in Cellular Neuroscience Pub Date : 2024-09-05 DOI:10.3389/fncel.2024.1437144
Chu Hua Chang, Kah Leong Lim, Jia Nee Foo
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Abstract

Synaptic Vesicle Glycoprotein 2C (SV2C), characterized by its selective expression in discrete brain regions such as the midbrain, has recently emerged as a promising player in Parkinson’s Disease (PD) – a debilitating neurodegenerative disorder affecting millions worldwide. This review aims to consolidate our current understanding of SV2C’s function, its involvement in PD pathogenesis, and to evaluate its potential as a therapeutic target. Integrating previous findings of SV2C, from genetics to molecular studies, and drawing on insights from the largest East Asian genome-wide association study that highlights SV2C as a novel risk factor for PD, we explore the potential pathways through which SV2C may influence the disease. Our discussion extends to the implications of SV2C’s role in synaptic vesicle trafficking, neurotransmitter release, and α-synuclein homeostasis, thereby laying the groundwork for future investigations that could pave the way for novel therapeutic strategies in combating PD.
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突触小泡糖蛋白 2C:在帕金森病中的作用
突触小泡糖蛋白2C(SV2C)的特点是在中脑等离散脑区选择性表达,最近它已成为帕金森病(PD)--一种影响全球数百万人的令人衰弱的神经退行性疾病--中的一个有希望的角色。本综述旨在巩固我们目前对SV2C功能的认识,了解其在帕金森病发病机制中的参与情况,并评估其作为治疗靶点的潜力。从遗传学到分子研究,我们综合了以往对SV2C的研究结果,并借鉴了东亚最大的全基因组关联研究(该研究强调SV2C是一种新型的帕金森病风险因素)的见解,探讨了SV2C可能影响该疾病的潜在途径。我们的讨论延伸到SV2C在突触囊泡贩运、神经递质释放和α-突触核蛋白稳态中的作用的意义,从而为未来的研究奠定基础,这些研究可能为抗击帕金森病的新型治疗策略铺平道路。
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来源期刊
CiteScore
7.90
自引率
3.80%
发文量
627
审稿时长
6-12 weeks
期刊介绍: Frontiers in Cellular Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the cellular mechanisms underlying cell function in the nervous system across all species. Specialty Chief Editors Egidio D‘Angelo at the University of Pavia and Christian Hansel at the University of Chicago are supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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