Metal-organic frameworks in oral drug delivery

IF 10.7 1区 医学 Q1 PHARMACOLOGY & PHARMACY Asian Journal of Pharmaceutical Sciences Pub Date : 2024-10-01 DOI:10.1016/j.ajps.2024.100951
Aun Raza , Wei Wu
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Abstract

Metal-organic frameworks (MOFs) offer innovative solutions to the limitations of traditional oral drug delivery systems through their unique combination of metal ions and organic ligands. This review systematically examines the structural properties and principles of MOFs, setting the stage for their application in drug delivery. It discusses various classes of MOFs, including those based on zirconium, iron, zinc, copper, titanium, aluminum, potassium, and magnesium, assessing their drug-loading capacities, biocompatibility, and controlled release mechanisms. The effectiveness of MOFs is illustrated through case studies that highlight their capabilities in enhancing drug solubility, providing protection against the harsh gastrointestinal environment, and enabling precise drug release. The review addresses potential challenges, particularly the toxicity concerns associated with MOFs, and calls for further research into their biocompatibility and interactions with biological systems. It concludes by emphasizing the potential of MOFs in revolutionizing oral drug delivery, highlighting the critical need for comprehensive research to harness their full potential in clinical applications.

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口服给药中的金属有机框架
金属有机框架(MOFs)通过金属离子和有机配体的独特组合,为传统口服给药系统的局限性提供了创新性解决方案。本综述系统研究了 MOFs 的结构特性和原理,为其在给药领域的应用奠定了基础。文章讨论了各类 MOFs,包括基于锆、铁、锌、铜、钛、铝、钾和镁的 MOFs,评估了它们的药物负载能力、生物相容性和控释机制。MOFs 在提高药物溶解度、抵御严酷的胃肠道环境以及实现药物精确释放等方面的功效,通过案例研究得以体现。综述探讨了潜在的挑战,特别是与 MOFs 相关的毒性问题,并呼吁进一步研究 MOFs 的生物相容性以及与生物系统的相互作用。综述最后强调了 MOFs 在革新口服给药方面的潜力,并强调亟需开展全面研究,以充分发挥其在临床应用中的潜力。
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来源期刊
Asian Journal of Pharmaceutical Sciences
Asian Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
18.30
自引率
2.90%
发文量
11
审稿时长
14 days
期刊介绍: The Asian Journal of Pharmaceutical Sciences (AJPS) serves as the official journal of the Asian Federation for Pharmaceutical Sciences (AFPS). Recognized by the Science Citation Index Expanded (SCIE), AJPS offers a platform for the reporting of advancements, production methodologies, technologies, initiatives, and the practical application of scientific knowledge in the field of pharmaceutics. The journal covers a wide range of topics including but not limited to controlled drug release systems, drug targeting, physical pharmacy, pharmacodynamics, pharmacokinetics, pharmacogenomics, biopharmaceutics, drug and prodrug design, pharmaceutical analysis, drug stability, quality control, pharmaceutical engineering, and material sciences.
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