Complex formation and stabilization of Z-isomer-enriched astaxanthin esters derived from Haematococcus lacustris with water-soluble carriers via spray drying
Rina Sakaguchi, Antara Ghosh, Sujan Banik, Yasuhiro Nishida, Masaki Honda
{"title":"Complex formation and stabilization of Z-isomer-enriched astaxanthin esters derived from Haematococcus lacustris with water-soluble carriers via spray drying","authors":"Rina Sakaguchi, Antara Ghosh, Sujan Banik, Yasuhiro Nishida, Masaki Honda","doi":"10.1002/ejlt.202400101","DOIUrl":null,"url":null,"abstract":"<p>To enhance the water solubility and bioavailability of astaxanthin esters, inclusion complexes of <i>Z</i>-isomer-enriched astaxanthin esters with water-soluble carriers were prepared using a spray drying technique. A food-grade <i>Haematococcus</i> alga extract was used as the source of astaxanthin esters, and the <i>Z</i>-isomerization was performed via direct heating of the extract. Polyvinylpyrrolidone (PVP) and hydroxypropyl-β-cyclodextrin (HP-β-CD) were used as water-soluble carriers. The effects of spray drying conditions on the encapsulation efficiency of astaxanthin esters in the carriers and the total <i>Z</i>-isomer ratio of encapsulated astaxanthin esters were investigated, and the physical properties and storage stability of the resulting composites were evaluated. Under optimum spray drying conditions, efficient production of highly water-soluble <i>Z</i>-isomer-rich astaxanthin esters was achieved in both carriers: >95% encapsulation efficiency and >55% total <i>Z</i>-isomer ratio. The physical properties, such as surface morphology and particle size distributions, of the resulting particles differed significantly between PVP and HP-β-CD. Storage tests demonstrated that the formulated <i>Z</i>-isomer-rich astaxanthin esters were highly stable. Our findings will contribute to the practical applications of <i>Z</i>-isomer-rich astaxanthin materials.</p><p><i>Practical Applications</i>: The formulation technology developed in this study has the potential to address the industrial challenges of using astaxanthin, that is, low water solubility and low bioavailability. Furthermore, the low storage stability of astaxanthin <i>Z</i>-isomers, which hinders their industrial use, can be solved simultaneously. The resulting <i>Z</i>-isomer-rich astaxanthin powders are expected to be used in a wide range of applications, including nutraceuticals, cosmetics, and animal feeds.</p>","PeriodicalId":11988,"journal":{"name":"European Journal of Lipid Science and Technology","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Lipid Science and Technology","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ejlt.202400101","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
To enhance the water solubility and bioavailability of astaxanthin esters, inclusion complexes of Z-isomer-enriched astaxanthin esters with water-soluble carriers were prepared using a spray drying technique. A food-grade Haematococcus alga extract was used as the source of astaxanthin esters, and the Z-isomerization was performed via direct heating of the extract. Polyvinylpyrrolidone (PVP) and hydroxypropyl-β-cyclodextrin (HP-β-CD) were used as water-soluble carriers. The effects of spray drying conditions on the encapsulation efficiency of astaxanthin esters in the carriers and the total Z-isomer ratio of encapsulated astaxanthin esters were investigated, and the physical properties and storage stability of the resulting composites were evaluated. Under optimum spray drying conditions, efficient production of highly water-soluble Z-isomer-rich astaxanthin esters was achieved in both carriers: >95% encapsulation efficiency and >55% total Z-isomer ratio. The physical properties, such as surface morphology and particle size distributions, of the resulting particles differed significantly between PVP and HP-β-CD. Storage tests demonstrated that the formulated Z-isomer-rich astaxanthin esters were highly stable. Our findings will contribute to the practical applications of Z-isomer-rich astaxanthin materials.
Practical Applications: The formulation technology developed in this study has the potential to address the industrial challenges of using astaxanthin, that is, low water solubility and low bioavailability. Furthermore, the low storage stability of astaxanthin Z-isomers, which hinders their industrial use, can be solved simultaneously. The resulting Z-isomer-rich astaxanthin powders are expected to be used in a wide range of applications, including nutraceuticals, cosmetics, and animal feeds.
期刊介绍:
The European Journal of Lipid Science and Technology is a peer-reviewed journal publishing original research articles, reviews, and other contributions on lipid related topics in food science and technology, biomedical science including clinical and pre-clinical research, nutrition, animal science, plant and microbial lipids, (bio)chemistry, oleochemistry, biotechnology, processing, physical chemistry, and analytics including lipidomics. A major focus of the journal is the synthesis of health related topics with applied aspects.
Following is a selection of subject areas which are of special interest to EJLST:
Animal and plant products for healthier foods including strategic feeding and transgenic crops
Authentication and analysis of foods for ensuring food quality and safety
Bioavailability of PUFA and other nutrients
Dietary lipids and minor compounds, their specific roles in food products and in nutrition
Food technology and processing for safer and healthier products
Functional foods and nutraceuticals
Lipidomics
Lipid structuring and formulations
Oleochemistry, lipid-derived polymers and biomaterials
Processes using lipid-modifying enzymes
The scope is not restricted to these areas. Submissions on topics at the interface of basic research and applications are strongly encouraged. The journal is the official organ the European Federation for the Science and Technology of Lipids (Euro Fed Lipid).