Complex formation and stabilization of Z-isomer-enriched astaxanthin esters derived from Haematococcus lacustris with water-soluble carriers via spray drying

IF 1.8 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY European Journal of Lipid Science and Technology Pub Date : 2024-09-08 DOI:10.1002/ejlt.202400101
Rina Sakaguchi, Antara Ghosh, Sujan Banik, Yasuhiro Nishida, Masaki Honda
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Abstract

To enhance the water solubility and bioavailability of astaxanthin esters, inclusion complexes of Z-isomer-enriched astaxanthin esters with water-soluble carriers were prepared using a spray drying technique. A food-grade Haematococcus alga extract was used as the source of astaxanthin esters, and the Z-isomerization was performed via direct heating of the extract. Polyvinylpyrrolidone (PVP) and hydroxypropyl-β-cyclodextrin (HP-β-CD) were used as water-soluble carriers. The effects of spray drying conditions on the encapsulation efficiency of astaxanthin esters in the carriers and the total Z-isomer ratio of encapsulated astaxanthin esters were investigated, and the physical properties and storage stability of the resulting composites were evaluated. Under optimum spray drying conditions, efficient production of highly water-soluble Z-isomer-rich astaxanthin esters was achieved in both carriers: >95% encapsulation efficiency and >55% total Z-isomer ratio. The physical properties, such as surface morphology and particle size distributions, of the resulting particles differed significantly between PVP and HP-β-CD. Storage tests demonstrated that the formulated Z-isomer-rich astaxanthin esters were highly stable. Our findings will contribute to the practical applications of Z-isomer-rich astaxanthin materials.

Practical Applications: The formulation technology developed in this study has the potential to address the industrial challenges of using astaxanthin, that is, low water solubility and low bioavailability. Furthermore, the low storage stability of astaxanthin Z-isomers, which hinders their industrial use, can be solved simultaneously. The resulting Z-isomer-rich astaxanthin powders are expected to be used in a wide range of applications, including nutraceuticals, cosmetics, and animal feeds.

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通过喷雾干燥法,从漆膜血球藻中提取的富含 Z 异构体的虾青素酯与水溶性载体形成复合物并使其稳定化
为了提高虾青素酯的水溶性和生物利用率,采用喷雾干燥技术制备了富含 Z-异构体的虾青素酯与水溶性载体的包合物。虾青素酯的来源是食品级血球藻提取物,Z-异构化是通过直接加热提取物实现的。聚乙烯吡咯烷酮(PVP)和羟丙基-β-环糊精(HP-β-CD)被用作水溶性载体。研究了喷雾干燥条件对虾青素酯类在载体中的包封效率和包封虾青素酯类的总 Z 异构体比的影响,并对所得复合材料的物理性质和储存稳定性进行了评估。在最佳喷雾干燥条件下,两种载体均能高效生产出富含Z-异构体的高水溶性虾青素酯:封装效率达95%,总Z-异构体比率达55%。PVP 和 HP-β-CD 所产生颗粒的物理性质(如表面形态和粒度分布)差异显著。贮存测试表明,配制的富含 Z-异构体的虾青素酯具有很高的稳定性。我们的研究结果将有助于富含 Z-异构体的虾青素材料的实际应用:本研究开发的配方技术有望解决虾青素在工业应用中的难题,即低水溶性和低生物利用率。此外,还可同时解决虾青素 Z-异构体储存稳定性低这一阻碍其工业应用的问题。由此获得的富含 Z-异构体的虾青素粉末有望被广泛应用于营养保健品、化妆品和动物饲料等领域。
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来源期刊
CiteScore
5.50
自引率
0.00%
发文量
101
审稿时长
6-16 weeks
期刊介绍: The European Journal of Lipid Science and Technology is a peer-reviewed journal publishing original research articles, reviews, and other contributions on lipid related topics in food science and technology, biomedical science including clinical and pre-clinical research, nutrition, animal science, plant and microbial lipids, (bio)chemistry, oleochemistry, biotechnology, processing, physical chemistry, and analytics including lipidomics. A major focus of the journal is the synthesis of health related topics with applied aspects. Following is a selection of subject areas which are of special interest to EJLST: Animal and plant products for healthier foods including strategic feeding and transgenic crops Authentication and analysis of foods for ensuring food quality and safety Bioavailability of PUFA and other nutrients Dietary lipids and minor compounds, their specific roles in food products and in nutrition Food technology and processing for safer and healthier products Functional foods and nutraceuticals Lipidomics Lipid structuring and formulations Oleochemistry, lipid-derived polymers and biomaterials Processes using lipid-modifying enzymes The scope is not restricted to these areas. Submissions on topics at the interface of basic research and applications are strongly encouraged. The journal is the official organ the European Federation for the Science and Technology of Lipids (Euro Fed Lipid).
期刊最新文献
Cover Picture: Eur. J. Lipid Sci. Technol. 11/2024 Editorial Board: Eur. J. Lipid Sci. Technol. 11/2024 Contents: Eur. J. Lipid Sci. Technol. 11/2024 One step beyond for CNSL-based plasticizers for PVC: Use of cardol Cover Picture: Eur. J. Lipid Sci. Technol. 10/2024
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