Dielectric Resonators for Microwave Hyperthermia

Abstract

Hyperthermia, utilizing various types of energy sources such as microwaves, holds great promise for cancer treatment. The intense interaction between microwaves and substances during hyperthermia can produce heat efficiently, leading to the inactivation of cancer cells. Mie-type resonance is widely studied in the regulation of electromagnetic waves, offering a new perspective for microwave hyperthermia. In this study, a Mie-type dielectric resonator is reported for microwave hyperthermia using high-permittivity and temperature-stable ceramic. The proposed dielectric particles have the characteristics of compact size, low cost, and excellent biocompatibility. The resonant frequency of the system can be finely tuned through material design and arrangement, thus expanding its potential application scenarios. The dielectric particles can be rapidly heated under microwave irradiation, thereby enabling effective hyperthermia to eliminate cancer cells. This work demonstrates the potential of a safe and tunable Mie-type dielectric resonator in microwave hyperthermia, which is expected to promote further research on Mie-type resonance in the biomedical field.