C-reactive protein in anhedonia among patients with major depressive disorder and its relation to suicidal ideation

IF 1.5 Q3 PSYCHIATRY Middle East Current Psychiatry Pub Date : 2024-08-30 DOI:10.1186/s43045-024-00453-2

Hani H. Dessoki, Mohamed R. Soltan, Ahmed S. Ragheb, Mariam E. Dawoud

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Abstract

There is evidence that major depressive disorder (MDD) with its cardinal symptoms, anhedonia and suicide, are linked with raised inflammatory markers like C-reactive protein (CRP). This case–control study investigated the correlation between high sensitive CRP (Hs-CRP), anhedonia, suicidal ideation, and depression severity in MDD patients. Forty-one MDD patients and 47 healthy controls were recruited. MDD diagnosis was confirmed using DSM-5 criteria. Depression severity, anhedonia, and suicidal ideation were assessed using standardized scales. Serum Hs-CRP levels were measured as an inflammatory marker. MDD cases had significantly greater Hs-CRP levels compared to controls. Additionally, Hs-CRP levels were positively correlated with both anhedonia and suicidal ideation in MDD cases. Depression severity was significantly linked with both anhedonia and suicidal ideation. This study suggests a link between inflammation, anhedonia, suicidal ideation, and depression severity in MDD patients. Additional research is necessary to find out the principal mechanisms.

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重度抑郁症患者厌世情绪中的 C 反应蛋白及其与自杀意念的关系

有证据表明，重度抑郁症（MDD）及其主要症状--失神和自杀--与 C 反应蛋白（CRP）等炎症标志物的升高有关。这项病例对照研究调查了 MDD 患者的高敏 CRP（Hs-CRP）、厌世情绪、自杀意念和抑郁严重程度之间的相关性。研究招募了 41 名 MDD 患者和 47 名健康对照者。MDD 诊断根据 DSM-5 标准进行确认。抑郁严重程度、厌世情绪和自杀意念采用标准化量表进行评估。血清 Hs-CRP 水平作为炎症标志物进行了测量。与对照组相比，MDD 患者的 Hs-CRP 水平明显更高。此外，在 MDD 患者中，Hs-CRP 水平与厌世情绪和自杀意念呈正相关。抑郁症的严重程度与失乐症和自杀意念均有明显关联。这项研究表明，MDD 患者的炎症、失乐症、自杀意念和抑郁严重程度之间存在联系。要找出其主要机制，还需要进行更多的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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