A Comprehensive Review on Phage Therapy and Phage-Based Drug Development

Longzhu Cui, Shinya Watanabe, Kazuhiko Miyanaga, Kotaro Kiga, Teppei Sasahara, Yoshifumi Aiba, Xin-Ee Tan, Srivani Veeranarayanan, Kanate Thitiananpakorn, Huong Minh Nguyen, Dhammika Leshan Wannigama
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Abstract

Phage therapy, the use of bacteriophages (phages) to treat bacterial infections, is regaining momentum as a promising weapon against the rising threat of multidrug-resistant (MDR) bacteria. This comprehensive review explores the historical context, the modern resurgence of phage therapy, and phage-facilitated advancements in medical and technological fields. It details the mechanisms of action and applications of phages in treating MDR bacterial infections, particularly those associated with biofilms and intracellular pathogens. The review further highlights innovative uses of phages in vaccine development, cancer therapy, and as gene delivery vectors. Despite its targeted and efficient approach, phage therapy faces challenges related to phage stability, immune response, and regulatory approval. By examining these areas in detail, this review underscores the immense potential and remaining hurdles in integrating phage-based therapies into modern medical practices.
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噬菌体疗法和噬菌体药物开发综述
噬菌体疗法是一种利用噬菌体治疗细菌感染的方法,它作为对抗日益严重的耐多药(MDR)细菌威胁的有力武器,正在重新获得发展势头。本综述探讨了噬菌体疗法的历史背景、现代噬菌体疗法的复苏以及噬菌体在医疗和技术领域推动的进步。它详细介绍了噬菌体治疗 MDR 细菌感染的作用机制和应用,尤其是与生物膜和细胞内病原体相关的感染。该综述进一步强调了噬菌体在疫苗开发、癌症治疗以及基因递送载体方面的创新应用。尽管噬菌体疗法是一种有针对性的高效方法,但它也面临着与噬菌体稳定性、免疫反应和监管审批有关的挑战。通过对这些领域的详细研究,本综述强调了将噬菌体疗法融入现代医疗实践的巨大潜力和仍然存在的障碍。
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