An adaptable, fit-for-purpose screening approach with high-throughput capability to determine speed of action and stage specificity of anti-malarial compounds

IF 4.1 2区 医学 Q2 MICROBIOLOGY Antimicrobial Agents and Chemotherapy Pub Date : 2024-09-12 DOI:10.1128/aac.00746-24
Sandra DuffyBrad E. SleebsVicky M. Avery1Discovery Biology, School of Environment and Science, Griffith University, Griffith, Australia2The Walter and Eliza Hall Institute of Medical Research, The University of Melbourne, Parkville, Australia3Department of Medical Biology, The Walter and Eliza Hall Institute of Medical Research, The University of Melbourne, Parkville, AustraliaAudrey Odom John
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Abstract

Antimicrobial Agents and Chemotherapy, Ahead of Print.
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一种具有高通量能力的适应性强的筛选方法,可确定抗疟疾化合物的作用速度和阶段特异性
抗菌剂与化疗》,印刷版前。
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来源期刊
CiteScore
10.00
自引率
8.20%
发文量
762
审稿时长
3 months
期刊介绍: Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.
期刊最新文献
Analogs of the anti-malaria drug mefloquine have broad-spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection. High frequency of acquired virulence factors in carbapenemase-producing Klebsiella pneumoniae isolates from a large German university hospital, 2013-2021. Impact of porin deficiency on the synergistic potential of colistin in combination with β-lactam/β-lactamase inhibitors against ESBL- and carbapenemase-producing Klebsiella pneumoniae. Relative inhibitory activities of newly developed diazabicyclooctanes, boronic acid derivatives, and penicillin-based sulfone β-lactamase inhibitors against broad-spectrum AmpC β-lactamases. Oral oxaborole MRX-5 exhibits efficacy against pulmonary Mycobacterium abscessus in mouse.
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