Tommaso Pavan, Pascal Steullet, Yasser Alemán-Gómez, Raoul Jenni, Zoé Schilliger, Martine Cleusix, Luis Alameda, Kim Q. Do, Philippe Conus, Patric Hagmann, Daniella Dwir, Paul Klauser, Ileana Jelescu
{"title":"Associations Between Blood Markers of the GSH Redox cycle and Brain White Matter Microstructure in Psychosis","authors":"Tommaso Pavan, Pascal Steullet, Yasser Alemán-Gómez, Raoul Jenni, Zoé Schilliger, Martine Cleusix, Luis Alameda, Kim Q. Do, Philippe Conus, Patric Hagmann, Daniella Dwir, Paul Klauser, Ileana Jelescu","doi":"10.1101/2024.09.02.24312940","DOIUrl":null,"url":null,"abstract":"In groups of patients suffering from psychosis, redox dysregulation was reported in both peripheral fluids and brain. It has been hypothesized that such dysregulation, including alterations of the glutathione (GSH) cycle could participate in the brain white matter (WM) abnormalities in schizophrenia (SZ) due to the oligodendrocytes’ susceptibility to oxidative stress (OxS).","PeriodicalId":501388,"journal":{"name":"medRxiv - Psychiatry and Clinical Psychology","volume":"192 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Psychiatry and Clinical Psychology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.09.02.24312940","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
In groups of patients suffering from psychosis, redox dysregulation was reported in both peripheral fluids and brain. It has been hypothesized that such dysregulation, including alterations of the glutathione (GSH) cycle could participate in the brain white matter (WM) abnormalities in schizophrenia (SZ) due to the oligodendrocytes’ susceptibility to oxidative stress (OxS).
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