Sequence-activated chemiluminescence probes: programmable illumination for high-contrast in vivo sensing and imaging

IF 10.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Science China Chemistry Pub Date : 2024-09-03 DOI:10.1007/s11426-024-2143-0

Yutao Zhang, Juan Li, Wei-Hong Zhu, Zhiqian Guo

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Abstract

Sequence-activated chemiluminescence (CL) technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial resolution. The fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest, thus enabling high-contrast signals under complex physiological conditions. This sequential activation could be triggered by enzymes, reactive oxygen species (ROS), biothiols or changes in the microenvironment. These unique sequence-activated CL probes bestow several advantages, including minimal background, deep-tissue penetration, and the ability of non-invasive or minimally invasive detection. The sequence-activated CL techniques represent a significant advancement in molecular imaging and diagnostics. In this mini-review, we focus on the latest developments in sequential CL probes, addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

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序列激活的化学发光探针：用于高对比度体内传感和成像的可编程照明

序列激活化学发光（CL）技术为高灵敏度和高空间分辨率检测特定生物分子或细胞事件提供了一种独特的方法。序列激活化学发光探针的基本原理是针对特定序列或相关事件定制高度可控的化学发光信号，从而在复杂的生理条件下实现高对比度信号。这种序列激活可能由酶、活性氧（ROS）、生物硫醇或微环境变化触发。这些独特的序列激活 CL 探针具有多种优势，包括本底极低、深层组织穿透以及无创或微创检测能力。序列激活 CL 技术代表了分子成像和诊断技术的重大进步。在这篇微型综述中，我们将重点介绍序列激活发光二极管探针的最新发展，探讨其技术挑战，并讨论利用发光二极管信号传导和分子识别技术的未来发展轨迹。

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来源期刊

Science China Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

14.40

自引率

7.30%

发文量

3787

审稿时长

2.2 months

期刊介绍： Science China Chemistry, co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China and published by Science China Press, publishes high-quality original research in both basic and applied chemistry. Indexed by Science Citation Index, it is a premier academic journal in the field. Categories of articles include: Highlights. Brief summaries and scholarly comments on recent research achievements in any field of chemistry. Perspectives. Concise reports on thelatest chemistry trends of interest to scientists worldwide, including discussions of research breakthroughs and interpretations of important science and funding policies. Reviews. In-depth summaries of representative results and achievements of the past 5–10 years in selected topics based on or closely related to the research expertise of the authors, providing a thorough assessment of the significance, current status, and future research directions of the field.