Neurodegenerative Plasma Biomarkers for Prediction of Hippocampal Atrophy in Older Adults with Suspected Alzheimer’s Disease in Kinshasa, Democratic Republic of Congo
Jean Ikanga, Kharine Jean, Priscilla Medina, Saranya Sundaram Patel, Megan Schwinne, Emmanuel Epenge, Guy Gikelekele, Nathan Tshengele, Immaculee Kavugho, Samuel Mampunza, Lelo Mananga, Charlotte E. Teunissen, Anthony Stringer, Julio C. Rojas, Brandon Chan, Argentina Lario Lago, Joel H. Kramer, Adam L. Boxer, Andreas Jeromin, Bernard Hanseeuw, Alden L. Gross, Alvaro Alonso
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Abstract
Objective The hippocampus is one of the first brain structures affected by Alzheimer’s disease (AD), and its atrophy is a strong indicator of the disease. This study investigates the ability of plasma biomarkers of AD and AD-related dementias— amyloid-β (Aβ42/40), phosphorylated tau-181 (p-tau181), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP)—to predict hippocampal atrophy in adult individuals in Kinshasa, Democratic Republic of Congo (DRC).
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