Connectome-based predictive modeling of brain pathology and cognition in Autosomal Dominant Alzheimer’s Disease

Abstract

INTRODUCTION Autosomal Dominant Alzheimer’s Disease (ADAD) through genetic mutations can result in near complete expression of the disease. Tracking AD pathology development in an ADAD cohort of Presenilin-1 (PSEN1) E280A carriers’ mutation has allowed us to observe incipient tau tangles accumulation as early as 6 years prior to symptom onset.