Suzanne G. Orchard, Zhen Zhou, Michelle Fravel, Joanne Ryan, Robyn L. Woods, Rory Wolfe, Raj C. Shah, Anne Murray, Ajay Sood, Christopher M. Reid, Mark R. Nelson, Lawrie Bellin, Kevan R Polkinghorne, Nigel Stocks, Michael E. Ernst
{"title":"Antihypertensive medications and dementia in older adults with hypertension","authors":"Suzanne G. Orchard, Zhen Zhou, Michelle Fravel, Joanne Ryan, Robyn L. Woods, Rory Wolfe, Raj C. Shah, Anne Murray, Ajay Sood, Christopher M. Reid, Mark R. Nelson, Lawrie Bellin, Kevan R Polkinghorne, Nigel Stocks, Michael E. Ernst","doi":"10.1101/2024.08.28.24312754","DOIUrl":null,"url":null,"abstract":"<strong>Background</strong> Studies on middle-aged or individuals with cognitive or cardiovascular impairments, have established that intensive blood pressure (BP) control reduces cognitive decline risk. However, uncertainty exists on differential effects between antihypertensive medications (AHM) classes on this risk, independent of BP-lowering efficacy, particularly in community-dwelling hypertensive older adults.","PeriodicalId":501367,"journal":{"name":"medRxiv - Neurology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Neurology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.08.28.24312754","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background Studies on middle-aged or individuals with cognitive or cardiovascular impairments, have established that intensive blood pressure (BP) control reduces cognitive decline risk. However, uncertainty exists on differential effects between antihypertensive medications (AHM) classes on this risk, independent of BP-lowering efficacy, particularly in community-dwelling hypertensive older adults.
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