Safety evaluation of extracorporeal shockwave lithotripsy for pancreatic stones: Experience based on a large chronic pancreatitis cohort.

IF 4 3区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Digestive and Liver Disease Pub Date : 2024-09-10 DOI:10.1016/j.dld.2024.08.043
Yu Liu,Jin-Hui Yi,Peng-Yuan Wang,Peng Fu,Ying Kang,Teng Wang,Di Zhang,Xi-Hong Zhang,Jin-Jie Xu,Song-Lin Zhang,Pei-Dong Han,Fan Wang,Xiao-Yu Zhou,Jia-Sheng Feng,Jia-Jun Xu,Jia-Hao Qian,Dan Wang,Hui Chen,Run-Hui Liu,Fang-Yu Wang,Zhao-Shen Li,Liang-Hao Hu
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Abstract

BACKGROUND The safety of extracorporeal shock wave lithotripsy for pancreatic stones (P-ESWL) and adverse events were not evaluated and classified within large sample population. This study aimed to evaluate the safety and classify the adverse events of P-ESWL based on a large sample cohort. METHODS This is an observational study based on the large prospective chronic pancreatitis (CP) cohort. Patients with painful pancreatic stones over 5 mm who underwent P-ESWL between March 2011 and June 2018 at Shanghai Changhai Hospital were included. Adverse events after P-ESWL including complications and transient adverse events (TAEs) were recorded. Risk factors of adverse events were analyzed through univariable and multivariable logistics regression analysis. Sensitivity analysis was conducted to test the stability of the study. RESULTS Totally 2,071 patients underwent 5,002 sessions of P-ESWL were included. The overall complication rate and TAEs rate after all P-ESWL procedures were 5.2% and 20.9%. The complications and TAEs rate decreased obviously within the first 6 sessions. Several independent risk factors for adverse events after P-ESWL were identified. Sensitivity analysis suggested the stability of the results. CONCLUSIONS P-ESWL is a safe treatment for pancreatic stones. Multiple P-ESWL sessions did not increase the complications and TAEs rate. ClincialTrials.gov number, NCT05916547.
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体外冲击波碎石治疗胰腺结石的安全性评估:基于大型慢性胰腺炎队列的经验。
背景体外冲击波碎石治疗胰腺结石(P-ESWL)的安全性和不良反应尚未在大样本人群中进行评估和分类。本研究旨在基于大样本队列对胰腺结石体外冲击波碎石术的安全性和不良事件进行评估和分类。研究纳入了2011年3月至2018年6月期间在上海长海医院接受P-ESWL治疗的5毫米以上疼痛性胰腺结石患者。记录了P-ESWL术后的不良事件,包括并发症和一过性不良事件(TAE)。通过单变量和多变量物流回归分析对不良事件的风险因素进行了分析。结果总共有2,071名患者接受了5,002次P-ESWL治疗。所有 P-ESWL 手术后的总并发症发生率和 TAEs 发生率分别为 5.2% 和 20.9%。并发症和 TAEs 发生率在前 6 个疗程中明显下降。研究发现,P-ESWL术后发生不良事件的几个独立风险因素。结论SP-ESWL是一种安全的胰腺结石治疗方法。结论SP-ESWL是一种安全的胰腺结石治疗方法,多次P-ESWL治疗不会增加并发症和TAEs发生率。ClincialTrials.gov 编号:NCT05916547。
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来源期刊
Digestive and Liver Disease
Digestive and Liver Disease 医学-胃肠肝病学
CiteScore
6.10
自引率
2.20%
发文量
632
审稿时长
19 days
期刊介绍: Digestive and Liver Disease is an international journal of Gastroenterology and Hepatology. It is the official journal of Italian Association for the Study of the Liver (AISF); Italian Association for the Study of the Pancreas (AISP); Italian Association for Digestive Endoscopy (SIED); Italian Association for Hospital Gastroenterologists and Digestive Endoscopists (AIGO); Italian Society of Gastroenterology (SIGE); Italian Society of Pediatric Gastroenterology and Hepatology (SIGENP) and Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD). Digestive and Liver Disease publishes papers on basic and clinical research in the field of gastroenterology and hepatology. Contributions consist of: Original Papers Correspondence to the Editor Editorials, Reviews and Special Articles Progress Reports Image of the Month Congress Proceedings Symposia and Mini-symposia.
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