Sex differences in Helicobacter pylori infection and recurrence rate among 81,754 Chinese adults: a cross-sectional study

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-09-11 DOI:10.1186/s12876-024-03404-7
Yuqin Qiao, Yun Zhou, Li Zhao, Shengyi Yang, Xiaodong Zhang, Shixiong Liu
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Abstract

To compare the sex differences of Helicobacter pylori (HP) infection rate and 1-year recurrence rate. A cross-sectional study was conducted on the prevalence of HP infection in 81,754 people who underwent physical examination in physical examination centers and outpatient clinics of the Affiliated Hospital of Gansu University of Traditional Chinese Medicine, the Second People’s Hospital of Zhangye City, Tianshui City Hospital of Integrated Chinese and Western Medicine, the First and Second Department of The First Hospital of Lanzhou University Physical Examination Center, from March 2010 to December 2019. Among them, 53,771 (65.77%) were males (18–91 years old) and 27,983 (34.23%) were females (18–94 years old). According to age, they were divided into young group, middle-aged group and old group. 1448 asymptomatic infected patients were selected and treated with bismuth-containing quadruple drug eradication therapy for 2 weeks. The eradication rate and recurrence rate after 1 year were compared between males and females. The overall infection rate was 49.59%, including 49.74% in males and 49.3% in females. The risk of infection in young women was lower than that in men (OR = 0.908, 95%CI: 0.868–0.95, P < 0.01), the risk of infection in older women was higher than that in men (OR = 1.137, 95%CI: 1.041–1.243, P < 0.01). The female infection rate was positively correlated with age from 18 to 60, and Spearman’s correlation coefficient was 0.825 (P < 0.01). The overall eradication rate was 84.67% in intention-to-treat analysis (ITT) and 88.46% in protocol analysis (PP). The eradication rates of ITT and PP in the older group were 78.38% and 82.27%, respectively, which were lower than 87.25% and 89.39% in the male group (P < 0.05). The 1-year overall recurrence rate was 3.86%, including 2.82% in males and 5.44% in females (P < 0.05), female was a risk factor for recurrence after eradication after controlling for age (OR = 2.177, 95%CI 1.166–4.066, P < 0.05). There were no obvious adverse reactions during the treatment. There is a positive linear correlation between HP infection rate and age increase in women. Older women have the characteristics of high HP infection rate, low eradication rate and high recurrence rate.
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81 754 名中国成年人幽门螺杆菌感染和复发率的性别差异:一项横断面研究
比较幽门螺杆菌(HP)感染率和1年复发率的性别差异。2010年3月至2019年12月,对甘肃中医药大学附属医院、张掖市第二人民医院、天水市中西医结合医院、兰州大学第一医院体检中心一、二部体检中心及门诊的81754名体检者的HP感染率进行了横断面研究。其中,男性(18-91 岁)53771 人,占 65.77%;女性(18-94 岁)27983 人,占 34.23%。按年龄分为青年组、中年组和老年组。选取 1448 名无症状感染者,对其进行为期 2 周的含铋四联药物根除治疗。比较了男性和女性的根除率和 1 年后的复发率。总感染率为 49.59%,其中男性为 49.74%,女性为 49.3%。年轻女性的感染风险低于男性(OR = 0.908,95%CI:0.868-0.95,P < 0.01),而老年女性的感染风险高于男性(OR = 1.137,95%CI:1.041-1.243,P < 0.01)。女性感染率与 18 至 60 岁的年龄呈正相关,斯皮尔曼相关系数为 0.825(P < 0.01)。意向治疗分析(ITT)的总体根除率为 84.67%,方案分析(PP)的总体根除率为 88.46%。老年组的ITT和PP根除率分别为78.38%和82.27%,低于男性组的87.25%和89.39%(P < 0.05)。1年总复发率为3.86%,其中男性为2.82%,女性为5.44%(P < 0.05),在控制年龄后,女性是根除后复发的危险因素(OR = 2.177,95%CI 1.166-4.066,P < 0.05)。治疗期间无明显不良反应。女性 HP 感染率与年龄增长呈正线性关系。老年妇女具有 HP 感染率高、根除率低和复发率高的特点。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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