Intradialytic oral nutrition effects on malnourished hemodialysis patients: a randomized trial

IF 3.8 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Scientific Reports Pub Date : 2024-09-13 DOI:10.1038/s41598-024-72402-2

Bancha Satirapoj, Tanin Apiyangkool, Paramat Thimachai, Naowanit Nata, Ouppatham Supasyndh

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Abstract

Oral nutritional supplementation (ONS) is recommended for malnourished hemodialysis patients when their nutritional intake remains inadequate to meet energy and protein requirements. Patients were randomized into two groups: the intradialytic ONS supplements (INTRA-ONS) group (N = 16) and the interdialytic ONS supplements (INTER-ONS) group (N = 16) for a duration of 12 weeks. Malnutrition inflammation score (MIS) and serum albumin levels were assessed. The total MIS decreased significantly in patients from both the INTRA-ONS group (− 6.13, 95% CI − 8.29 to − 3.96) and the INTER-ONS group (− 3.50, 95% CI − 5.56 to − 1.35). A significant difference in the change of MIS was observed between the two groups (− 3.06, 95% CI − 5.94 to − 0.17). No significant differences were observed between the groups concerning serum albumin levels, dietary intake, anthropometric measurements, or body weight. Intradialytic ONS demonstrates similar benefits on nutritional biomarkers but improves the MIS among malnourished ESRD patients compared to interdialytic ONS.

Trial registration Thai Clinical Trials Registry (TCTR) identification number is TCTR20220322007: 16/09/2021.

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对营养不良的血液透析患者进行胰内口服营养的效果：随机试验

当营养摄入仍不足以满足能量和蛋白质需求时，建议营养不良的血液透析患者口服营养补充剂（ONS）。患者被随机分为两组：血液透析内营养补充剂（INTRA-ONS）组（16 人）和血液透析间营养补充剂（INTER-ONS）组（16 人），为期 12 周。对营养不良炎症评分（MIS）和血清白蛋白水平进行了评估。INTRA-ONS组（- 6.13，95% CI - 8.29 至 - 3.96）和INTER-ONS组（- 3.50，95% CI - 5.56 至 - 1.35）患者的营养不良炎症总评分均明显下降。两组在 MIS 变化方面存在明显差异（- 3.06，95% CI - 5.94 至 - 0.17）。在血清白蛋白水平、饮食摄入量、人体测量或体重方面，两组之间未发现明显差异。椎管内 ONS 对营养生物标志物的益处相似，但与椎管间 ONS 相比，可改善营养不良 ESRD 患者的 MIS：16/09/2021.

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来源期刊

Scientific Reports Natural Science Disciplines-

CiteScore

7.50

自引率

4.30%

发文量

19567

审稿时长

3.9 months

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