Impact of diet intervention on visceral adipose tissue and hepatic fat in patients with obesity or type 2 diabetes: a randomized trial

IF 3.8 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Scientific Reports Pub Date : 2024-09-13 DOI:10.1038/s41598-024-72246-w

Rungroj Krittayaphong, Witcha Treesuwan, Pornpoj Pramyothin, Thammarak Songsangjinda, Yodying Kaolawanich, Weerachai Srivanichakorn, Preechaya Jangtawee, Ahthit Yindeengam, Prajak Tanapibunpon, Apichart Vanavichit

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Abstract

This study aimed to assess the effects of a diet intervention on visceral and hepatic fat in patients with obesity or type 2 diabetes (T2D). Participants with obesity or T2D were randomized to a diet intervention or their usual diet. The intervention comprised a “3G rice” regimen combined with a low-salt, high-fiber diet. The primary outcomes were changes in visceral adipose tissue (VAT) area and hepatic fat over 12 weeks assessed by magnetic resonance imaging. Eighty-six patients were randomized. Their mean age was 47.5 ± 11.0 years, and 82.3% were female. Eighty-one (94.2%) had obesity, and 16 (18.6%) had T2D. Baseline metrics were body weight 76.3 ± 16.1 kg, BMI 29.6 ± 4.6, VAT 12 629 ± 5819 mm², and hepatic fat 7.9% ± 7.2%. At the 12-week follow-up, the diet group had greater VAT and hepatic fat reductions than controls (− 1468 ± 1468 vs. − 179 ± 1576 mm², P = 0.001; and − 2.6% ± 3.4% vs. 0.4% ± 2.2%, P < 0.001). Adjusted differences remained significant for VAT (− 1093 mm², P < 0.001) and hepatic fat (− 2.5%, P < 0.001). In conclusion, the 12-week diet intervention decreased VAT, hepatic fat, body weight, and BMI compared to a usual diet.

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饮食干预对肥胖症或 2 型糖尿病患者内脏脂肪组织和肝脏脂肪的影响：随机试验

这项研究旨在评估饮食干预对肥胖症或 2 型糖尿病（T2D）患者内脏和肝脏脂肪的影响。患有肥胖症或 T2D 的参与者被随机分配到饮食干预或常规饮食中。干预措施包括 "3G 米饭 "方案和低盐高纤维饮食。主要结果是通过磁共振成像评估内脏脂肪组织（VAT）面积和肝脏脂肪在12周内的变化。86名患者被随机分配。他们的平均年龄为 47.5 ± 11.0 岁，82.3% 为女性。81人（94.2%）患有肥胖症，16人（18.6%）患有T2D。基线指标为体重（76.3 ± 16.1）公斤、体重指数（29.6 ± 4.6）、VAT（12 629 ± 5819）平方毫米、肝脏脂肪（7.9% ± 7.2%）。在 12 周的随访中，与对照组相比，节食组的 VAT 和肝脏脂肪减少幅度更大（- 1468 ± 1468 vs. - 179 ± 1576 mm2，P<0.05）。- 179 ± 1576 mm2，P = 0.001；- 2.6% ± 3.4% vs. 0.4% ± 2.2%，P <0.001）。经调整后，VAT（- 1093 mm2，P = 0.001）和肝脏脂肪（- 2.5%，P = 0.001）的差异仍然显著。总之，与普通饮食相比，为期 12 周的饮食干预可减少脂肪体积、肝脏脂肪、体重和体重指数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Scientific Reports Natural Science Disciplines-

CiteScore

7.50

自引率

4.30%

发文量

19567

审稿时长

3.9 months

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