Can Psychedelic Use Benefit Meditation Practice? Examining Individual, Psychedelic, and Meditation-Related Factors

Zishan Jiwani, Simon Goldberg, Jack Stroud, Jacob Young, John Curtin, John D. Dunne, Otto Simonsson, Christian A. Webb, Robin Carhart-Harris, Marco Schlosser
{"title":"Can Psychedelic Use Benefit Meditation Practice? Examining Individual, Psychedelic, and Meditation-Related Factors","authors":"Zishan Jiwani, Simon Goldberg, Jack Stroud, Jacob Young, John Curtin, John D. Dunne, Otto Simonsson, Christian A. Webb, Robin Carhart-Harris, Marco Schlosser","doi":"10.1101/2024.08.27.24312677","DOIUrl":null,"url":null,"abstract":"Introduction: Meditation practice and psychedelic use have attracted increasing attention in the public sphere and scientific research. Both methods induce non-ordinary states of consciousness that may have significant therapeutic benefits. Thus, there is growing scientific interest in potential synergies between psychedelic use and meditation practice with some research suggesting that psychedelics may benefit meditation practice. The present study examined individual, psychedelic-related, and meditation-related factors to determine under what conditions meditators perceive psychedelic use as beneficial for their meditation practice.\nMethod: Participants (N = 863) who had reported psychedelic use and a regular meditation practice (at least 3 times per week during the last 12 months) were included in the study. To accommodate a large number of variables, machine learning (i.e., elastic net, random forest) was used to analyze the data. Results: Most participants (n = 634, 73.5%) found psychedelic use to have a positive influence on their quality of meditation. Twenty-eight variables showed significant zero-order associations with perceived benefits even following a correction. Elastic net had the best performance (R2 = .266) and was used to identify the most important features. Across 53 variables, the model found that greater use of psychedelics, intention setting during psychedelic use, agreeableness, and exposure to N,N-Dimethyltryptamine (N,N-DMT) were most likely to be associated with the perception that psychedelics benefit meditation practice. The results were consistent across several different approaches used to identify the most important variables (i.e., Shapley values, feature ablation).\nDiscussion: Results suggest that most meditators found psychedelic use to have a positive influence on their meditation practice, with: 1) regularity of psychedelic use, 2) the setting of intentions for psychedelic use, 3) having an agreeable personality, and 4) reported use of N,N-DMT being the most likely predictors of perceiving psychedelic use as beneficial. Longitudinal designs and randomized trials manipulating psychedelic use are needed to establish causality.","PeriodicalId":501447,"journal":{"name":"medRxiv - Pharmacology and Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Pharmacology and Therapeutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.08.27.24312677","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction: Meditation practice and psychedelic use have attracted increasing attention in the public sphere and scientific research. Both methods induce non-ordinary states of consciousness that may have significant therapeutic benefits. Thus, there is growing scientific interest in potential synergies between psychedelic use and meditation practice with some research suggesting that psychedelics may benefit meditation practice. The present study examined individual, psychedelic-related, and meditation-related factors to determine under what conditions meditators perceive psychedelic use as beneficial for their meditation practice. Method: Participants (N = 863) who had reported psychedelic use and a regular meditation practice (at least 3 times per week during the last 12 months) were included in the study. To accommodate a large number of variables, machine learning (i.e., elastic net, random forest) was used to analyze the data. Results: Most participants (n = 634, 73.5%) found psychedelic use to have a positive influence on their quality of meditation. Twenty-eight variables showed significant zero-order associations with perceived benefits even following a correction. Elastic net had the best performance (R2 = .266) and was used to identify the most important features. Across 53 variables, the model found that greater use of psychedelics, intention setting during psychedelic use, agreeableness, and exposure to N,N-Dimethyltryptamine (N,N-DMT) were most likely to be associated with the perception that psychedelics benefit meditation practice. The results were consistent across several different approaches used to identify the most important variables (i.e., Shapley values, feature ablation). Discussion: Results suggest that most meditators found psychedelic use to have a positive influence on their meditation practice, with: 1) regularity of psychedelic use, 2) the setting of intentions for psychedelic use, 3) having an agreeable personality, and 4) reported use of N,N-DMT being the most likely predictors of perceiving psychedelic use as beneficial. Longitudinal designs and randomized trials manipulating psychedelic use are needed to establish causality.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
使用迷幻剂对冥想练习有益吗?研究个人、迷幻药和冥想相关因素
导言:冥想练习和使用迷幻药在公共领域和科学研究中引起了越来越多的关注。这两种方法都能诱发非凡的意识状态,可能具有显著的治疗效果。因此,科学界对使用迷幻药和冥想练习之间潜在的协同作用越来越感兴趣,一些研究表明迷幻药可能有益于冥想练习。本研究考察了个人、迷幻药相关因素和冥想相关因素,以确定在什么条件下冥想者认为使用迷幻药有利于冥想练习:本研究的参与者(N = 863)均表示曾使用过迷幻药并定期进行冥想练习(在过去 12 个月中每周至少 3 次)。为了适应大量变量,研究人员使用了机器学习(即弹性网、随机森林)来分析数据。研究结果大多数参与者(n = 634,73.5%)认为使用迷幻药对他们的冥想质量有积极影响。即使经过校正,仍有 28 个变量显示出与感知到的益处有明显的零阶关联。弹力网的表现最好(R2 = 0.266),被用来识别最重要的特征。在 53 个变量中,该模型发现,更多使用迷幻药、使用迷幻药期间的意向设定、合群性以及接触 N,N-二甲基色胺(N,N-DMT)最有可能与迷幻药有益于冥想练习的认知相关。通过几种不同的方法(如夏普利值、特征消减)来确定最重要的变量,结果是一致的:讨论:结果表明,大多数冥想者认为使用迷幻药对他们的冥想练习有积极影响,其中包括1)定期使用迷幻药;2)设定使用迷幻药的意向;3)性格开朗;4)报告使用过 N,N-DMT,这些因素最有可能预测使用迷幻药是否有益。要确定因果关系,还需要对迷幻药的使用进行纵向设计和随机试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Tucaresol: An Oral Candidate Drug With Two Distinct Antiviral Mechanisms. Comparative Risk of the Onset of Atrial Fibrillation after Icosapent Ethyl versus Omega-3–Acid-Ethyl-Esters Adjuvant to Statins A Novel Maxillofacial Technology for Drug Administration-A Randomized Controlled Trial Using Metronidazole. Protective Effects of Psychiatric Medications against COVID-19 Mortality Before Vaccines Anti-cancer effect of memantine as adjunctive therapy in metastatic colon cancer: A pilot randomized controlled clinical trial
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1