Chinese utility weights for the EORTC cancer-specific utility instrument QLU-C10D

IF 3.3 3区医学 Q1 HEALTH CARE SCIENCES & SERVICES Quality of Life Research Pub Date : 2024-09-13 DOI:10.1007/s11136-024-03776-z

Yiyin Cao, Juan Xu, Richard Norman, Madeleine T. King, Georg Kemmler, Weidong Huang, Nan Luo

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Abstract

Objective

The aim of this study is to provide Chinese utility weights for the European Organization for Research and Treatment of Cancer Quality of Life Utility Measure-Core 10 Dimensions (EORTC QLU-C10D) which is a preference-based cancer-specific utility instrument derived from the EORTC QLQ-C30.

Methods

We conducted an online survey of the general population in China, with quota sampling for age and gender. Each respondent was asked to complete a discrete choice experimental survey consisting of 16 randomly selected choice sets. The conditional logit model and mixed logit model were used to analyze respondents’ preferences, and the goodness of fit of the model was tested.

Results

A total of 2003 respondents were included in the analysis. Utility decrements within dimensions were typically monotonic. Monotonic inconsistency issues in the Fatigue, Sleep, and Nausea dimensions were normalized by monotonicity correction. Physical functioning, Pain, and Role functioning were associated with the greatest utility weights, with the smallest decrements being in Bowel problems and Emotional functioning. The utility value for the worst health state was 0.083, i.e. slightly higher than being dead.

Conclusions

This study provides the first China-specific set of value for the QLU-C10D based on societal preferences of the Chinese adult general population. The value set can be used as a cancer-specific scoring system for economic evaluations of new oncology therapies and technologies in China.

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EORTC 癌症特异性效用工具 QLU-C10D 的中国效用权重

本研究旨在为欧洲癌症研究和治疗组织生活质量效用测量--核心 10 维（EORTC QLU-C10D）提供中国效用权重。每位受访者都被要求完成一项离散选择实验调查，其中包括 16 个随机选择集。我们使用条件 logit 模型和混合 logit 模型来分析受访者的偏好，并检验了模型的拟合度。各维度内的效用递减通常是单调的。疲劳、睡眠和恶心维度中的单调性不一致性问题通过单调性校正进行了归一化处理。身体功能、疼痛和角色功能的效用权重最大，排便问题和情绪功能的效用权重下降最小。最差健康状况的效用值为 0.083，即略高于死亡。这套数值可作为中国肿瘤新疗法和新技术经济评估的癌症特异性评分系统。

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来源期刊

Quality of Life Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

8.60%

发文量

224

审稿时长

3-8 weeks

期刊介绍： Quality of Life Research is an international, multidisciplinary journal devoted to the rapid communication of original research, theoretical articles and methodological reports related to the field of quality of life, in all the health sciences. The journal also offers editorials, literature, book and software reviews, correspondence and abstracts of conferences. Quality of life has become a prominent issue in biometry, philosophy, social science, clinical medicine, health services and outcomes research. The journal''s scope reflects the wide application of quality of life assessment and research in the biological and social sciences. All original work is subject to peer review for originality, scientific quality and relevance to a broad readership. This is an official journal of the International Society of Quality of Life Research.