Changes in hypothalamic subunits volume and their association with metabolic parameters and gastrointestinal appetite-regulating hormones following bariatric surgery

Amélie Lachance, Justine Daoust, Mélissa Pelletier, Alexandre Caron, André C. Carpentier, Laurent Biertho, Josefina Maranzano, André Tchernof, Mahsa Dadar, Andréanne Michaud
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Abstract

Background Some nuclei of the hypothalamus are known for their important roles in maintaining energy homeostasis and regulating food intake. Moreover, obesity has been associated with hypothalamic inflammation and morphological alterations, as indicated by increased volume. However, the reversibility of these changes after bariatric surgery-induced weight loss remains underexplored.
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减肥手术后下丘脑亚单位体积的变化及其与代谢参数和胃肠道食欲调节激素的关系
背景 众所周知,下丘脑的一些核团在维持能量平衡和调节食物摄入方面发挥着重要作用。此外,肥胖还与下丘脑炎症和形态改变有关,表现为体积增大。然而,这些变化在减肥手术引起的体重减轻后的可逆性仍未得到充分探索。
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