{"title":"ANGIOTENSIN CONVERTING ENZYME HUB CAPACITY - A SIMPLE MODEL OF RELATING PEPTIDE FLUX AND RENIN INFLUENCE","authors":"Brian M Westwood, Mark C Chappell","doi":"10.1101/2024.08.20.608830","DOIUrl":null,"url":null,"abstract":"As the Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) Trial was not designed to measure Renin-Angiotensin-Aldosterone System components, this hub model was developed to limit eight components to a system with one entrance and two exits to facilitate the calculation of angiotensinogen levels. Bootstrapping the bioactive peptide egress rate constant using control subjects and incorporating the previously established renin relationship, the model was used to develop a contingency test to index and classify component relationships.","PeriodicalId":501213,"journal":{"name":"bioRxiv - Systems Biology","volume":"12 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"bioRxiv - Systems Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.08.20.608830","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
As the Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) Trial was not designed to measure Renin-Angiotensin-Aldosterone System components, this hub model was developed to limit eight components to a system with one entrance and two exits to facilitate the calculation of angiotensinogen levels. Bootstrapping the bioactive peptide egress rate constant using control subjects and incorporating the previously established renin relationship, the model was used to develop a contingency test to index and classify component relationships.
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