Trevor S Barlowe,Shruti Saxena-Beem,Rumey C Ishizawar,Hans Herfarth,Andrew M Moon
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引用次数: 0
Abstract
OBJECTIVES
Describe immune related adverse events (irAE) affecting multiple organs of the gastrointestinal system in patients who received immune checkpoint inhibitors (ICI).
METHODS
Within a 2843-patient retrospective cohort consisting of patients with cancer treated with ICIs, EMERSE (Electronic Medical Record Search Engine), an information retrieval system, was used to search free text in the medical record to identify patients with multiple gastrointestinal irAEs.
RESULTS
13 patients developed multiple gastrointestinal irAEs (0.46%). The most common patterns of multisystem gastrointestinal irAE were colitis + pancreatitis and colitis + enteritis.
CONCLUSIONS
Multisystem gastrointestinal irAEs are rare but warrant further characterization and attention.
期刊介绍：
Clinical and Translational Gastroenterology (CTG), published on behalf of the American College of Gastroenterology (ACG), is a peer-reviewed open access online journal dedicated to innovative clinical work in the field of gastroenterology and hepatology. CTG hopes to fulfill an unmet need for clinicians and scientists by welcoming novel cohort studies, early-phase clinical trials, qualitative and quantitative epidemiologic research, hypothesis-generating research, studies of novel mechanisms and methodologies including public health interventions, and integration of approaches across organs and disciplines. CTG also welcomes hypothesis-generating small studies, methods papers, and translational research with clear applications to human physiology or disease.
Colon and small bowel
Endoscopy and novel diagnostics
Esophagus
Functional GI disorders
Immunology of the GI tract
Microbiology of the GI tract
Inflammatory bowel disease
Pancreas and biliary tract
Liver
Pathology
Pediatrics
Preventative medicine
Nutrition/obesity
Stomach.
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