{"title":"Antiproliferative Activity Compounds Isolated from the Marine Fungus Penicillium terrigenum","authors":"Fan-ying Wu, Si-yuan Liu, Jie Feng","doi":"10.1007/s11094-024-03204-z","DOIUrl":null,"url":null,"abstract":"<p>Cancer is still one of the greatest threats to human health. Marine fungi are abundant in constituents that can cause various bioactivities for many purposes. Compounds are the basis of drug development, leading to more studies on exploring these bioactive items. In this study, 9 compounds were isolated from <i>Penicillium terrigenum</i>. Four compounds isolated from the Trichocomaceae family, two compounds isolated from the <i>Penicillium</i> genus, as well as the other compounds, were all isolated from this strain for the first time. Compounds PTL-1 - PTL-6 were initially screened for antiproliferative activity on liver and lung cancer cells using the MTT assay <i>in vitro</i>. The results showed that the 6 compounds exhibited different antiproliferative activities. From the results, PTL-2, 7-ethylcamptothecin significantly inhibited the proliferation of cancer cells, highlighting it as a potential drug or lead compound.</p>","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutical Chemistry Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11094-024-03204-z","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Cancer is still one of the greatest threats to human health. Marine fungi are abundant in constituents that can cause various bioactivities for many purposes. Compounds are the basis of drug development, leading to more studies on exploring these bioactive items. In this study, 9 compounds were isolated from Penicillium terrigenum. Four compounds isolated from the Trichocomaceae family, two compounds isolated from the Penicillium genus, as well as the other compounds, were all isolated from this strain for the first time. Compounds PTL-1 - PTL-6 were initially screened for antiproliferative activity on liver and lung cancer cells using the MTT assay in vitro. The results showed that the 6 compounds exhibited different antiproliferative activities. From the results, PTL-2, 7-ethylcamptothecin significantly inhibited the proliferation of cancer cells, highlighting it as a potential drug or lead compound.
期刊介绍：
Pharmaceutical Chemistry Journal is a monthly publication devoted to scientific and technical research on the creation of new drugs and the improvement of manufacturing technology of drugs and intermediates. International contributors cover the entire spectrum of new drug research, including:
methods of synthesis;
results of pharmacological, toxicological, and biochemical studies;
investigation of structure - activity relationships in prediction of new compounds;
methods and technical facilities used; and
problems associated with the development of ecologically safe and economically feasible methods of industrial production.
In addition, analytical reviews of the international literature in the field provide coverage of the most recent developments around the world.
Pharmaceutical Chemistry Journal is a translation of the Russian journal Khimiko-Farmatsevticheskii Zhurnal. The Russian Volume Year is published in English from April.
All articles are peer-reviewed.
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