Synergistic effect of “methyl cellulose-dextran” on oral curcumin delivery via casein nanomicelle: fabrication, characterization, and cancer therapeutic efficacy assessment

IF 4.9 2区工程技术 Q1 MATERIALS SCIENCE, PAPER & WOOD Cellulose Pub Date : 2024-09-13 DOI:10.1007/s10570-024-06169-0

Samia F. Aboushoushah, Sana F. Abaza, Nihal S. Elbialy, Noha Mohamed

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Abstract

A casein-methyl cellulose nanocomplex, loaded with curcumin and coated with dextran (DX-CasCur-MC), is designed to enhance curcumin’s oral delivery and inhibit cancer growth. Its physicochemical properties reveal chemical bonding between protein and polysaccharides, transforming curcumin from crystalline into amorphous state to improve water solubility. The encapsulation efficiency of curcumin reaches 92%, and its release profile in physiological and tumor microenvironments exhibits controlled and sustained release. In vitro studies confirm the significant therapeutic efficacy of DX-CasCur-MC in inducing cancer cell death and DNA damage compared to free curcumin. The effectiveness of DX-CasCur-MC for oral drug delivery is validated in simulated gastrointestinal fluids, with 23 and 69% release in gastric and intestinal fluids, respectively. In vivo studies demonstrate a significant reduction in tumor volume in mice treated with DX-CasCur-MC compared to those treated with free curcumin or untreated, confirming DX-CasCur-MC’s ability to improve curcumin’s pharmacological properties and inhibit tumor growth via repeated oral administration. The conjugation of the two polysaccharides with the hydrocolloidal casein nanomicelles improves the nanocomplexes stability, making DX-CasCur-MC a promising natural candidate for oral curcumin delivery with a significant cancer therapeutic efficacy.

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甲基纤维素-葡聚糖 "对通过酪蛋白纳米胶束口服姜黄素递送的协同效应：制备、表征和癌症疗效评估

酪蛋白-甲基纤维素纳米复合物（DX-CasCur-MC）含有姜黄素并涂有葡聚糖，旨在增强姜黄素的口服给药效果并抑制癌症生长。它的理化特性揭示了蛋白质与多糖之间的化学键，将姜黄素从结晶状态转化为无定形状态，从而提高了水溶性。姜黄素的封装效率高达 92%，其在生理和肿瘤微环境中的释放曲线呈现出可控和持续释放的特点。体外研究证实，与游离姜黄素相比，DX-CasCur-MC 在诱导癌细胞死亡和 DNA 损伤方面具有显著疗效。在模拟胃肠液中，DX-CasCur-MC 的口服给药效果得到了验证，在胃液和肠液中的释放率分别为 23% 和 69%。体内研究表明，与接受游离姜黄素治疗或未接受治疗的小鼠相比，接受 DX-CasCur-MC 治疗的小鼠肿瘤体积明显缩小，这证实了 DX-CasCur-MC 能够改善姜黄素的药理特性，并通过反复口服抑制肿瘤生长。两种多糖与水胶体酪蛋白纳米细胞的共轭作用提高了纳米复合物的稳定性，使 DX-CasCur-MC 成为口服姜黄素的理想天然候选药物，具有显著的癌症疗效。

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来源期刊

Cellulose 工程技术-材料科学：纺织

CiteScore

10.10

自引率

10.50%

发文量

580

审稿时长

3-8 weeks

期刊介绍： Cellulose is an international journal devoted to the dissemination of research and scientific and technological progress in the field of cellulose and related naturally occurring polymers. The journal is concerned with the pure and applied science of cellulose and related materials, and also with the development of relevant new technologies. This includes the chemistry, biochemistry, physics and materials science of cellulose and its sources, including wood and other biomass resources, and their derivatives. Coverage extends to the conversion of these polymers and resources into manufactured goods, such as pulp, paper, textiles, and manufactured as well natural fibers, and to the chemistry of materials used in their processing. Cellulose publishes review articles, research papers, and technical notes.