Marine Microorganism Molecules as Potential Anti-Inflammatory Therapeutics

IF 4.9 2区 医学 Q1 CHEMISTRY, MEDICINAL Marine Drugs Pub Date : 2024-09-03 DOI:10.3390/md22090405
Malia Lasalo, Thierry Jauffrais, Philippe Georgel, Mariko Matsui
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Abstract

The marine environment represents a formidable source of biodiversity, is still largely unexplored, and has high pharmacological potential. Indeed, several bioactive marine natural products (MNPs), including immunomodulators, have been identified in the past decades. Here, we review how this reservoir of bioactive molecules could be mobilized to develop novel anti-inflammatory compounds specially produced by or derived from marine microorganisms. After a detailed description of the MNPs exerting immunomodulatory potential and their biological target, we will briefly discuss the challenges associated with discovering anti-inflammatory compounds from marine microorganisms.
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作为潜在抗炎治疗药物的海洋微生物分子
海洋环境是生物多样性的巨大源泉,但在很大程度上仍未被开发,而且具有很高的药理潜力。事实上,在过去几十年中,已经发现了多种具有生物活性的海洋天然产物(MNPs),包括免疫调节剂。在此,我们回顾了如何利用这一生物活性分子库来开发由海洋微生物专门生产或从海洋微生物中提取的新型抗炎化合物。在详细介绍了具有免疫调节潜力的 MNPs 及其生物靶标之后,我们将简要讨论从海洋微生物中发现抗炎化合物所面临的挑战。
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来源期刊
Marine Drugs
Marine Drugs 医学-医药化学
CiteScore
9.60
自引率
14.80%
发文量
671
审稿时长
1 months
期刊介绍: Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.
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