{"title":"PERSISTANCE OF AMPICILLIN IN THE INTRAUTERINE CONTENT FOLLOWING SINGLE AND MULTIPLE DOSES TO PREGNANT WOMEN","authors":"Agneta Philipson","doi":"10.1111/j.1600-0412.1981.tb00021.x","DOIUrl":null,"url":null,"abstract":"Cord plasma, and amniotic fluid (AF), as well as maternal plasma from women who had been given ampicillin in single or multiple doses prior to delivery were assayed for levels of the antibiotic. If medication had been discontinued two days prior to delivery or less, ampicillin could still be demonstrated in AF, where it remained demonstrable longer than in cord plasma. Ampicillin, when given during pregnancy, crosses the placenta, enters the fetal circulation, and is excreted by the fetal kidneys into the AF. The results of the present study indicate that as medication is continued, the level of ampicillin in AF rises through continuous renal excretion by the fetus. Once medication is discontinued, ampicillin is slowly cleared from the AF mainly through absorption from AF to fetal circulation and further passage to maternal circulation.","PeriodicalId":6990,"journal":{"name":"Acta Obstetricia et Gynecologica Scandinavica","volume":null,"pages":null},"PeriodicalIF":3.5000,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Obstetricia et Gynecologica Scandinavica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/j.1600-0412.1981.tb00021.x","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Cord plasma, and amniotic fluid (AF), as well as maternal plasma from women who had been given ampicillin in single or multiple doses prior to delivery were assayed for levels of the antibiotic. If medication had been discontinued two days prior to delivery or less, ampicillin could still be demonstrated in AF, where it remained demonstrable longer than in cord plasma. Ampicillin, when given during pregnancy, crosses the placenta, enters the fetal circulation, and is excreted by the fetal kidneys into the AF. The results of the present study indicate that as medication is continued, the level of ampicillin in AF rises through continuous renal excretion by the fetus. Once medication is discontinued, ampicillin is slowly cleared from the AF mainly through absorption from AF to fetal circulation and further passage to maternal circulation.
对脐带血浆、羊水(AF)以及分娩前服用过单剂或多剂氨苄西林的产妇的血浆进行了抗生素含量检测。如果在分娩前两天或更短时间内停药,氨苄西林仍可在羊水中显示出来,其在羊水中显示的时间长于在脐带血浆中显示的时间。氨苄西林在孕期可穿过胎盘,进入胎儿血液循环,并通过胎儿肾脏排泄到腹腔积液中。本研究的结果表明,随着药物治疗的持续,氨苄西林在胎儿肾脏排泄过程中会不断增加。一旦停药,氨苄西林主要通过胎儿血液循环和母体血液循环慢慢从 AF 中清除。
期刊介绍:
Published monthly, Acta Obstetricia et Gynecologica Scandinavica is an international journal dedicated to providing the very latest information on the results of both clinical, basic and translational research work related to all aspects of women’s health from around the globe. The journal regularly publishes commentaries, reviews, and original articles on a wide variety of topics including: gynecology, pregnancy, birth, female urology, gynecologic oncology, fertility and reproductive biology.