Chris Siu Yeung Chow, Sumedha Negi, Shaine Chenxin Bao, Chen Fang, James Edward Hudson, Woo Jun Shim, Yuanzhao Cao, Nathan Palpant
{"title":"A community-oriented, data-driven resource to improve protocol design for cardiac modelling from human pluripotent stem cells","authors":"Chris Siu Yeung Chow, Sumedha Negi, Shaine Chenxin Bao, Chen Fang, James Edward Hudson, Woo Jun Shim, Yuanzhao Cao, Nathan Palpant","doi":"10.1101/2024.09.04.611313","DOIUrl":null,"url":null,"abstract":"Protocols for culturing cardiac cells derived from human-induced pluripotent stem cells (hiPSCs) are critical for studying mechanisms of development and disease. This study provides analysis of a community-oriented database to assess parameters used in published cardiac differentiation protocols, including a web-accessible portal for user-guided customisation of protocols. Validation studies support context-dependent roles for media composition in deriving functional maturation of hiPSC-derived cardiomyocytes.","PeriodicalId":501269,"journal":{"name":"bioRxiv - Developmental Biology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"bioRxiv - Developmental Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.09.04.611313","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Protocols for culturing cardiac cells derived from human-induced pluripotent stem cells (hiPSCs) are critical for studying mechanisms of development and disease. This study provides analysis of a community-oriented database to assess parameters used in published cardiac differentiation protocols, including a web-accessible portal for user-guided customisation of protocols. Validation studies support context-dependent roles for media composition in deriving functional maturation of hiPSC-derived cardiomyocytes.
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