{"title":"Kinetoplast DNA: a polymer physicist's Olympic dream","authors":"Davide Michieletto","doi":"arxiv-2408.05978","DOIUrl":null,"url":null,"abstract":"All life forms are miraculous, but some are more inexplicable than others.\nTrypanosomes are by far one of the most puzzling organisms on Earth: their\nmitochondrial genome, also called kinetoplast DNA (kDNA) forms an\nOlympic-ring-like network of interlinked DNA circles, challenging conventional\nparadigms in both biology and physics. In this review, I will discuss kDNA from\nthe astonished perspective of a polymer physicist and tell a story of how a\nsingle sub-celluar structure from a blood-dwelling parasite is inspiring\ngenerations of polymer chemists and physicists to create new catenated\nmaterials.","PeriodicalId":501040,"journal":{"name":"arXiv - PHYS - Biological Physics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"arXiv - PHYS - Biological Physics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/arxiv-2408.05978","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
All life forms are miraculous, but some are more inexplicable than others.
Trypanosomes are by far one of the most puzzling organisms on Earth: their
mitochondrial genome, also called kinetoplast DNA (kDNA) forms an
Olympic-ring-like network of interlinked DNA circles, challenging conventional
paradigms in both biology and physics. In this review, I will discuss kDNA from
the astonished perspective of a polymer physicist and tell a story of how a
single sub-celluar structure from a blood-dwelling parasite is inspiring
generations of polymer chemists and physicists to create new catenated
materials.
锥虫是迄今为止地球上最令人费解的生物之一：它们的半软核基因组（又称动粒 DNA（kDNA））形成了一个由相互连接的 DNA 圈组成的奥林匹克环状网络，挑战了生物学和物理学的传统范式。在这篇综述中，我将从一个高分子物理学家的惊奇视角来讨论 kDNA，并讲述一个故事：一个来自血栖寄生虫的亚细胞结构是如何激励一代又一代的高分子化学家和物理学家去创造新的复合材料的。
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