Azithromycin Treatment Response as a Probe to Attribute Bacterial Aetiologies of Diarrhoea using Molecular Diagnostics: A Reanalysis of the AntiBiotics for Children with severe Diarrhoea (ABCD) Trial
Jennifer Cornick, Sarah Elwood, James Platts-Mills, Patricia Pavlinac, Karim Manji, Chris Sudfeld, Christopher P. Duggan, Queen Dube, Naor Bar-Zeev, Karen Kotloff, Samba O Sow, Sunil Sazawal, Benson O Singa, Judd L Walson, Farah Qamar, Tahmeed Ahmed, Ayesha De Costa, Elizabeth T Rogawski McQuade
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Abstract
Background Multi-pathogen molecular diagnostics enable assignment of diarrhoea aetiology, but defining thresholds of pathogen quantity to accurately attribute aetiology is challenging in high-burden settings where coinfections are common. The Antibiotics for Children with severe Diarrhoea (ABCD) trial provides an opportunity to leverage the azithromycin treatment response to inform which diarrhoea episodes are bacterial.
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