A Descriptive Review on the Potential Use of Diatom Biosilica as a Powerful Functional Biomaterial: A Natural Drug Delivery System

IF 4.9 3区医学 Q1 PHARMACOLOGY & PHARMACY Pharmaceutics Pub Date : 2024-09-05 DOI:10.3390/pharmaceutics16091171

Sunggu Kang, Yeeun Woo, Yoseph Seo, Daehyeon Yoo, Daeryul Kwon, Hyunjun Park, Sang Deuk Lee, Hah Young Yoo, Taek Lee

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Abstract

Although various chemically synthesized materials are essential in medicine, food, and agriculture, they can exert unexpected side effects on the environment and human health by releasing certain toxic chemicals. Therefore, eco-friendly and biocompatible biomaterials based on natural resources are being actively explored. Recently, biosilica derived from diatoms has attracted attention in various biomedical fields, including drug delivery systems (DDS), due to its uniform porous nano-pattern, hierarchical structure, and abundant silanol functional groups. Importantly, the structural characteristics of diatom biosilica improve the solubility of poorly soluble substances and enable sustained release of loaded drugs. Additionally, diatom biosilica predominantly comprises SiO2, has high biocompatibility, and can easily hybridize with other DDS platforms, including hydrogels and cationic DDS, owing to its strong negative charge and abundant silanol groups. This review explores the potential applications of various diatom biosilica-based DDS in various biomedical fields, with a particular focus on hybrid DDS utilizing them.

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关于硅藻生物硅石作为一种强大功能生物材料的潜在用途的描述性综述：天然药物输送系统

虽然各种化学合成材料在医药、食品和农业中必不可少，但它们会释放出某些有毒化学物质，对环境和人类健康产生意想不到的副作用。因此，人们正在积极探索基于自然资源的生态友好型生物材料。最近，从硅藻中提取的生物二氧化硅因其均匀的多孔纳米形态、分层结构和丰富的硅烷醇官能团，在包括药物输送系统（DDS）在内的多个生物医学领域引起了关注。重要的是，硅藻生物二氧化硅的结构特征可提高溶解性差的物质的溶解度，并实现负载药物的持续释放。此外，硅藻生物二氧化硅主要由二氧化硅组成，具有很高的生物相容性，而且由于其带强负电荷和丰富的硅烷醇基团，很容易与其他 DDS 平台（包括水凝胶和阳离子 DDS）杂交。本综述探讨了各种基于硅藻生物二氧化硅的 DDS 在各个生物医学领域的潜在应用，尤其侧重于利用它们的混合 DDS。

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来源期刊

Pharmaceutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

7.90

自引率

11.10%

发文量

2379

审稿时长

16.41 days

期刊介绍： Pharmaceutics (ISSN 1999-4923) is an open access journal which provides an advanced forum for the science and technology of pharmaceutics and biopharmaceutics. It publishes reviews, regular research papers, communications, and short notes. Covered topics include pharmacokinetics, toxicokinetics, pharmacodynamics, pharmacogenetics and pharmacogenomics, and pharmaceutical formulation. Our aim is to encourage scientists to publish their experimental and theoretical details in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.