{"title":"Recent Advancements in Gallic Acid-Based Drug Delivery: Applications, Clinical Trials, and Future Directions","authors":"Ranjit K. Harwansh, Rohitas Deshmukh, Vijay Pratap Shukla, Dignesh Khunt, Bhupendra Gopalbhai Prajapati, Summya Rashid, Nemat Ali, Gehan M. Elossaily, Vijendra Kumar Suryawanshi, Arun Kumar","doi":"10.3390/pharmaceutics16091202","DOIUrl":null,"url":null,"abstract":"Gallic acid (GA) is a well-known herbal bioactive compound found in many herbs and foods like tea, wine, cashew nuts, hazelnuts, walnuts, plums, grapes, mangoes, blackberries, blueberries, and strawberries. GA has been reported for several pharmacological activities, such as antioxidant, inflammatory, antineoplastic, antimicrobial, etc. Apart from its incredible therapeutic benefits, it has been associated with low permeability and bioavailability issues, limiting their efficacy. GA belongs to BCS (Biopharmaceutics classification system) class III (high solubility and low probability). In this context, novel drug delivery approaches played a vital role in resolving these GA issues. Nanocarrier systems help improve drug moiety’s physical and chemical stability by encapsulating them into a lipidic or polymeric matrix or core system. In this regard, researchers have developed a wide range of nanocarrier systems for GA, including liposomes, transfersomes, niosomes, dendrimers, phytosomes, micelles, nanoemulsions, metallic nanoparticles, solid lipid nanoparticles (SLNs), nanoparticles, nanostructured lipid carriers, polymer conjugates, etc. In the present review, different search engines like Scopus, PubMed, ScienceDirect, and Google Scholar have been referred to for acquiring recent information on the theme of the work. Therefore, this review paper aims to emphasize several novel drug delivery systems, patents, and clinical updates of GA.","PeriodicalId":19894,"journal":{"name":"Pharmaceutics","volume":null,"pages":null},"PeriodicalIF":4.9000,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/pharmaceutics16091202","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Gallic acid (GA) is a well-known herbal bioactive compound found in many herbs and foods like tea, wine, cashew nuts, hazelnuts, walnuts, plums, grapes, mangoes, blackberries, blueberries, and strawberries. GA has been reported for several pharmacological activities, such as antioxidant, inflammatory, antineoplastic, antimicrobial, etc. Apart from its incredible therapeutic benefits, it has been associated with low permeability and bioavailability issues, limiting their efficacy. GA belongs to BCS (Biopharmaceutics classification system) class III (high solubility and low probability). In this context, novel drug delivery approaches played a vital role in resolving these GA issues. Nanocarrier systems help improve drug moiety’s physical and chemical stability by encapsulating them into a lipidic or polymeric matrix or core system. In this regard, researchers have developed a wide range of nanocarrier systems for GA, including liposomes, transfersomes, niosomes, dendrimers, phytosomes, micelles, nanoemulsions, metallic nanoparticles, solid lipid nanoparticles (SLNs), nanoparticles, nanostructured lipid carriers, polymer conjugates, etc. In the present review, different search engines like Scopus, PubMed, ScienceDirect, and Google Scholar have been referred to for acquiring recent information on the theme of the work. Therefore, this review paper aims to emphasize several novel drug delivery systems, patents, and clinical updates of GA.
没食子酸(GA)是一种著名的草药生物活性化合物,存在于许多草药和食物中,如茶、酒、腰果、榛子、核桃、李子、葡萄、芒果、黑莓、蓝莓和草莓。据报道,天麻具有多种药理活性,如抗氧化、抗炎、抗肿瘤、抗菌等。除了令人难以置信的治疗效果外,它还存在渗透性和生物利用度低的问题,从而限制了其药效。天麻属于 BCS(生物制药分类系统)第三类(高溶解度和低概率)。在这种情况下,新型给药方法在解决 GA 问题方面发挥了重要作用。纳米载体系统通过将药物分子封装到脂质或聚合物基质或核心系统中,有助于提高药物分子的物理和化学稳定性。在这方面,研究人员已经开发出多种用于 GA 的纳米载体系统,包括脂质体、转移体、niosomes、树枝状分子、植物体、胶束、纳米乳液、金属纳米颗粒、固体脂质纳米颗粒(SLNs)、纳米粒子、纳米结构脂质载体、聚合物共轭物等。本综述参考了不同的搜索引擎,如 Scopus、PubMed、ScienceDirect 和 Google Scholar,以获取有关工作主题的最新信息。因此,本综述旨在强调几种新型给药系统、专利以及 GA 的临床更新。
PharmaceuticsPharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
7.90
自引率
11.10%
发文量
2379
审稿时长
16.41 days
期刊介绍:
Pharmaceutics (ISSN 1999-4923) is an open access journal which provides an advanced forum for the science and technology of pharmaceutics and biopharmaceutics. It publishes reviews, regular research papers, communications, and short notes. Covered topics include pharmacokinetics, toxicokinetics, pharmacodynamics, pharmacogenetics and pharmacogenomics, and pharmaceutical formulation. Our aim is to encourage scientists to publish their experimental and theoretical details in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.