Single/ Multiple Dose Percutaneously Injected LR-PRP Enhances Union Rate in Fracture Delayed Unions: A Prospective Case Series

IF 1.1 4区医学 Q3 ORTHOPEDICS Indian Journal of Orthopaedics Pub Date : 2024-09-10 DOI:10.1007/s43465-024-01265-6

Kishor Kunal, Nitesh Gahlot, Neeraj Choudhary, Abhay Elhence

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Abstract

Background

Average bone healing times of common fractures in adults ranges from 3 to 12 weeks and is location dependent. Platelet Rich Plasma (PRP) stimulates natural healing process through growth factors contained in platelets and has been employed for the same in delayed unions.

Methods

All patients > 18 years and documented delayed union were included in the study. Patients were followed up monthly after each Leucocyte-rich PRP (LR-PRP) injection and a decision for repeat PRP injection was taken on basis of visible impression in radiograph after previous injection.

Results

Total 36 patients were studied in which 5 patients were lost to follow-up. Union was achieved in 28/31 (90.3%). 20 (71.4%) patients required only single PRP injections. 4 (14.3%) patients required 2 PRP injections, 3 (10.7%) patients required 3 PRP injections and 1 (3.6%) patient required 4 PRP injection. There was no significant correlation of number of PRPs to time from 1st PRP-union or time from last PPR- union.

Conclusion

Single/multiple dose percutaneously administered LR-PRP can be used as a fruitful alternative to catalyze union in patients having delayed union irrespective of site of injury.

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单剂量/多剂量经皮注射 LR-PRP 提高骨折延迟联合的联合率：前瞻性病例系列

背景成人常见骨折的平均骨愈合时间为 3 至 12 周不等，且与地点有关。富血小板血浆（PRP）通过血小板中所含的生长因子刺激自然愈合过程，已被用于延迟接合。研究方法将所有年龄在 18 岁以下且有延迟结合记录的患者纳入研究范围。每次注射富含白细胞的 PRP（LR-PRP）后，每月对患者进行随访，并根据上次注射后的 X 光片上的可见印记决定是否再次注射 PRP。28/31（90.3%）例患者实现了骨结合。20例（71.4%）患者只需注射一次 PRP。4名（14.3%）患者需要注射 2 次 PRP，3 名（10.7%）患者需要注射 3 次 PRP，1 名（3.6%）患者需要注射 4 次 PRP。结论单剂量/多剂量经皮给药 LR-PRP 可作为一种有效的替代方法，用于催化迟发性骨结合患者的骨结合，无论其受伤部位如何。

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来源期刊

Indian Journal of Orthopaedics ORTHOPEDICS-

CiteScore

1.80

自引率

0.00%

发文量

185

审稿时长

9 months

期刊介绍： IJO welcomes articles that contribute to Orthopaedic knowledge from India and overseas. We publish articles dealing with clinical orthopaedics and basic research in orthopaedic surgery. Articles are accepted only for exclusive publication in the Indian Journal of Orthopaedics. Previously published articles, articles which are in peer-reviewed electronic publications in other journals, are not accepted by the Journal. Published articles and illustrations become the property of the Journal. The copyright remains with the journal. Studies must be carried out in accordance with World Medical Association Declaration of Helsinki.