Ultra‐thin benzalkonium chloride‐doped poly(lactic acid) electrospun mat

IF 3.2 4区工程技术 Q2 ENGINEERING, CHEMICAL Polymer Engineering and Science Pub Date : 2024-08-18 DOI:10.1002/pen.26906

Sena Özdil Şener, Sema Samatya Yilmaz, Merve Dandan Doganci, Hüseyin Uzuner, Erdinc Doganci

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Abstract

In this study, poly(lactic acid), poly(ethylene glycol), and benzalkonium chloride with different concentrations (3, 5, 7, and 9%wt.) (PLA/PEG/BCL) composite electrospun mats were produced. PLA is a non‐toxic polymer with high biocompatibility and biodegradability. However, it may be fragile due to its structure. Therefore, in this study, PEG was used as a plasticizer to improve the structural properties of PLA and it was aimed at providing antibacterial properties by adding BCL salt. Its use as an antibacterial composite nanomaterial effective against Gram‐positive Staphylococcus aureus (S. aureus) and Gram‐negative Escherichia coli (E. coli) bacterial cultures and as a dermal wound dressing material has been examined in two different areas. The addition of BCL salt reduced the bead formation in PLA/PEG nanofibers and increased the homogeneity of fiber dispersion. 9% BCL‐doped composite nanofiber was obtained as the smoothest and most homogeneous surface. This mat was reported to have the highest ductility. The low Tm of pure BCL salt enabled the Tg temperature of PLA/PEG/BCL composite nanofibers to be observed. It was observed that as the BCL salt ratio increased, the T5 and T10 temperatures of the nanofibers decreased and then increased. BCL‐doped mats exhibited liquid absorption behavior in the range of 497%–708%. PLA/PEG/BCL composite nanofibers showed high toxicity to the L929 fibroblast cell line. So, it has been reported that it cannot be used as a dermal wound dressing. PLA/PEG/BCL composite nanomaterials were reported to have 99.99% antibacterial activity against E. coli and S. aureus. It was suggested that it could be used in antibacterial coating applications by taking into account modern nanocoating technology.Highlights

Poly(lactic acid), poly(ethylene glycol), and benzalkonium chloride (PLA/PEG/BCL) composite electrospun mats were produced.

The addition of BCL salt reduced the bead formation in PLA/PEG nanofibers and increased the homogeneity of fiber dispersion.

9% BCL‐doped composite nanofiber was obtained as the smoothest and most homogeneous surface.

PLA/PEG/BCL composite nanofibers showed high toxicity to the L929 fibroblast cell line.

PLA/PEG/BCL composite nanomaterials were reported to have 99.99% antibacterial activity against E. coli and S. aureus.

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掺杂苯扎氯铵的超薄聚（乳酸）电纺丝毡

本研究制备了不同浓度（3、5、7 和 9%重量比）的聚乳酸、聚乙二醇和苯扎氯铵（PLA/PEG/BCL）复合电纺垫。聚乳酸是一种无毒聚合物，具有很高的生物相容性和生物降解性。然而，由于其结构的原因，它可能比较脆弱。因此，在本研究中，使用 PEG 作为增塑剂来改善聚乳酸的结构特性，并通过添加 BCL 盐来提供抗菌特性。研究人员对聚乳酸作为抗菌复合纳米材料，对革兰氏阳性金黄色葡萄球菌（S. aureus）和革兰氏阴性大肠杆菌（E. coli）细菌培养物以及作为皮肤伤口敷料材料的两个不同领域进行了研究。添加 BCL 盐可减少聚乳酸/聚乙二醇纳米纤维中珠子的形成，并提高纤维分散的均匀性。9% 的掺 BCL 复合纳米纤维表面最光滑、最均匀。据报道，这种毡具有最高的延展性。由于纯 BCL 盐的 Tm 较低，因此可以观察到 PLA/PEG/BCL 复合纳米纤维的 Tg 温度。据观察，随着 BCL 盐比例的增加，纳米纤维的 T5 和 T10 温度先降低后升高。掺 BCL 的纤维毡的液体吸收率在 497%-708% 之间。聚乳酸/聚乙二醇/BCL 复合纳米纤维对 L929 成纤维细胞系具有高毒性。因此，据报道它不能用作皮肤伤口敷料。据报道，PLA/PEG/BCL 复合纳米材料对大肠杆菌和金黄色葡萄球菌具有 99.99% 的抗菌活性。亮点聚乳酸、聚乙二醇和苯扎氯铵（PLA/PEG/BCL）复合电纺垫被制备出来。BCL 盐的加入减少了聚乳酸/聚乙二醇纳米纤维中珠子的形成，提高了纤维分散的均匀性。9%的BCL掺杂复合纳米纤维表面最光滑、最均匀。聚乳酸/PEG/BCL复合纳米纤维对L929成纤维细胞系具有高毒性。据报道，聚乳酸/PEG/BCL 复合纳米材料对大肠杆菌和金黄色葡萄球菌具有 99.99% 的抗菌活性。

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来源期刊

Polymer Engineering and Science 工程技术-高分子科学

CiteScore

5.40

自引率

18.80%

发文量

329

审稿时长

3.7 months

期刊介绍： For more than 30 years, Polymer Engineering & Science has been one of the most highly regarded journals in the field, serving as a forum for authors of treatises on the cutting edge of polymer science and technology. The importance of PE&S is underscored by the frequent rate at which its articles are cited, especially by other publications - literally thousand of times a year. Engineers, researchers, technicians, and academicians worldwide are looking to PE&S for the valuable information they need. There are special issues compiled by distinguished guest editors. These contain proceedings of symposia on such diverse topics as polyblends, mechanics of plastics and polymer welding.