Preparation and Characterization of Polymeric Microbeads Incorporated with Reduced Graphene Oxide for Drug Delivery and Antibacterial Applications

IF 0.6 4区化学 Q4 CHEMISTRY, APPLIED Russian Journal of Applied Chemistry Pub Date : 2024-08-20 DOI:10.1134/s1070427224020085

Dharmender Pallerla, Sreekanth Reddy Obireddy, Jithendra Thammineni, Manohara Reddy Busha, Prasoona Gumpula, Sunkari Jyothi

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Abstract

Creating polymeric microbeads that can respond to stimuli and deliver drugs has various practical uses in the pharmaceutical industry. To address this need, we have developed a new type of pH-sensitive polymeric microbeads that can be used as carriers for drug delivery applications. The gelation method was used to create microbeads incorporated with reduced graphene oxide (rGO) for the controlled release of metronidazole using sodium alginate and locust bean gum. The synthesized rGO and microbeads were analyzed by FTIR, XRD, and SEM. In vitro release and swelling studies were performed at pH 7.4 and 2.0 at 37 ^oC. The release kinetics and mechanism are analyzed by fitting the release data into various kinetics models. The antibacterial activity of the generated microbeads was tested against B. subtilis, L. acidophilus, and S. mutans. The results suggest that the developed microbeads may serve as effective carriers for antibacterial treatment.

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用于药物输送和抗菌应用的还原石墨烯氧化物聚合物微珠的制备与表征

摘要创造能对刺激做出反应并能递送药物的聚合物微珠在制药业中具有多种实际用途。针对这一需求，我们开发了一种新型 pH 值敏感聚合物微珠，可用作药物输送应用的载体。我们采用凝胶化方法，利用海藻酸钠和槐豆胶制成了含有还原型氧化石墨烯（rGO）的微珠，用于甲硝唑的控释。傅立叶变换红外光谱、X 射线衍射和扫描电镜分析了合成的 rGO 和微珠。在 37 摄氏度、pH 值分别为 7.4 和 2.0 的条件下进行了体外释放和溶胀研究。通过将释放数据拟合到各种动力学模型中，分析了释放动力学和机理。测试了生成的微珠对枯草杆菌、嗜酸乳杆菌和变异杆菌的抗菌活性。结果表明，所开发的微珠可作为抗菌治疗的有效载体。

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来源期刊

Russian Journal of Applied Chemistry 化学-应用化学

CiteScore

1.60

自引率

11.10%

发文量

审稿时长

2-4 weeks

期刊介绍： Russian Journal of Applied Chemistry (Zhurnal prikladnoi khimii) was founded in 1928. It covers all application problems of modern chemistry, including the structure of inorganic and organic compounds, kinetics and mechanisms of chemical reactions, problems of chemical processes and apparatus, borderline problems of chemistry, and applied research.