Solubility Measurement and Model Correlation of 4-Acetoxyazetidin-2-one in 12 Pure Solvents and One Binary Solvent at 293.15 to 333.15 K

Abstract

The solubility of 4-acetoxyazetidin-2-one (4-AA) in twelve pure solvents (methanol, ethanol, ethyl acetate, n-butyl acetate, cyclohexane, n-hexane, n-heptane, tetrahydrofuran, chloroform, acetonitrile, acetone, and toluene) and one binary solvent system (ethyl acetate + n-heptane) was measured by a dynamic laser monitoring method at temperatures ranging from 293.15 to 333.15 K. The results indicated that the solubility of 4-AA increased with rising temperature and with a higher molar fraction of ethyl acetate in the binary solvent. Eight models (Apelblat, Van’t Hoff, λh, Wilson, NRTL, CNIBS/R–K, Apelblat–Jouyban–Acree, and Van’t Hoff–Jouyban–Acree) were used to correlate the solubility data. The results showed that the Van’t Hoff model best correlated with the experimental values in pure solvent, while, the CNIBS/R–K model demonstrated the highest fitting accuracy in the binary solvent system.