Two C23-Steroids and a New Isocoumarin Metabolite from Mangrove Sediment-Derived Fungus Penicillium sp. SCSIO 41429

IF 4.9 2区医学 Q1 CHEMISTRY, MEDICINAL Marine Drugs Pub Date : 2024-08-30 DOI:10.3390/md22090393

Lishan Huang, Chunmei Chen, Jian Cai, Yixin Chen, Yongyan Zhu, Bin Yang, Xuefeng Zhou, Yonghong Liu, Huaming Tao

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Abstract

Two new C23-steroids derivatives, cyclocitrinoic acid A (1) and cyclocitrinoic acid B (2), and a new isocoumarin metabolite, (3R,4S)-6,8-dihydroxy-3,4,5-trimethyl-7-carboxamidelisocoumarin (10), together with 12 known compounds (3–9, 11–15) were isolated from the mangrove-sediment fungus Penicillium sp. SCSIO 41429. The structures of the new compounds were comprehensively characterized by 1D and 2D NMR, HRESIMS and ECD calculation. All isolates were evaluated for pancreatic lipase (PL) inhibitory and antioxidant activities. The biological evaluation results revealed that compounds 2, 14 and 15 displayed weak or moderate inhibition against PL, with IC50 values of 32.77, 5.15 and 2.42 µM, respectively. In addition, compounds 7, 12 and 13 showed radical scavenging activities against DPPH, with IC50 values of 64.70, 48.13, and 75.54 µM, respectively. In addition, molecular docking results indicated that these compounds had potential for PL inhibitory and antioxidant activities, which provided screening candidates for antioxidants and a reduction in obesity.

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红树林沉积物衍生真菌青霉 SCSIO 41429 的两种 C23 类固醇和一种新的异香豆素代谢物

从红树林沉积物真菌青霉菌（Penicillium sp. SCSIO 41429）中分离出两种新的C23-类固醇衍生物环柠檬酸A（1）和环柠檬酸B（2），以及一种新的异香豆素代谢物(3R,4S)-6,8-二羟基-3,4,5-三甲基-7-甲酰胺基异香豆素（10）和12种已知化合物（3-9, 11-15）。通过一维和二维核磁共振、HRESIMS 和 ECD 计算，对新化合物的结构进行了全面鉴定。对所有分离物进行了胰脂肪酶（PL）抑制和抗氧化活性评价。生物学评价结果表明，化合物 2、14 和 15 对胰脂肪酶有微弱或中等程度的抑制作用，IC50 值分别为 32.77、5.15 和 2.42 µM。此外，化合物 7、12 和 13 对 DPPH 具有自由基清除活性，IC50 值分别为 64.70、48.13 和 75.54 µM。此外，分子对接结果表明，这些化合物具有潜在的 PL 抑制和抗氧化活性，为抗氧化剂和减少肥胖提供了筛选候选化合物。

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来源期刊

Marine Drugs 医学-医药化学

CiteScore

9.60

自引率

14.80%

发文量

671

审稿时长

1 months

期刊介绍： Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.