Prolonged thermal stress enhances mosquito tolerance to viral infection

Hugo D. Perdomo, Ayda Khorramnejad, Nfamara M. Cham, Alida Kropf, Davide Sogliani, Mariangela Bonizzoni
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Abstract

How and to what extent mosquito-virus interaction is influenced by climate change is a complex question of ecological and epidemiological relevance. We worked at the intersection between thermal biology and vector immunology and studied shifts in tolerance and resistance to the cell fusing agent virus (CFAV), a prominent component of the mosquito virome know to contribute to shaping mosquito vector competence, in warm-acclimated and warm-evolved Aedes albopictus mosquitoes. We show that the length of the thermal challenge influences the outcome of the infection with warm-evolved mosquitoes being more tolerant to CFAV infection, while warm-acclimated mosquitoes being more resistant and suffering from extensive fitness costs. These results highlight the importance of considering fluctuations in vector immunity in relation to the length of a thermal challenge to understand natural variation in vector response to viruses and frame realistic transmission models.
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长时间的热应力增强了蚊子对病毒感染的耐受性
蚊子与病毒之间的相互作用如何以及在多大程度上受到气候变化的影响,是一个具有生态学和流行病学意义的复杂问题。我们在热生物学和病媒免疫学的交叉点开展工作,研究了白纹伊蚊对细胞融合剂病毒(CFAV)的耐受性和抵抗力的变化,CFAV是蚊子病毒组的一个重要组成部分,被认为有助于塑造蚊子的病媒能力。我们的研究表明,热挑战的时间长短会影响感染的结果,暖进化蚊子对 CFAV 感染的耐受性更强,而暖气候蚊子的抵抗力更强,并承受着巨大的健康代价。这些结果凸显了考虑病媒免疫力波动与热挑战时间长短关系的重要性,以了解病媒对病毒反应的自然变化,并建立现实的传播模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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