Quince Seed Mucilage Mediated Biosynthesis of Gold Nanoparticles: Analysis of Its Anti-prostate Cancer and Antioxidant Properties

IF 4.7 3区工程技术 Q2 ENGINEERING, ENVIRONMENTAL Journal of Polymers and the Environment Pub Date : 2024-09-10 DOI:10.1007/s10924-024-03399-y

Jia Zhang, Tianjun Xing, Attalla F. El-kott, Ali G. Alkhathami, Abdullah A. Alamri

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Abstract

Herein, we have devised a green protocol for the biogenicmadeAu NPs mediated over natural and biological macromolecules derived from Quince (Cydoniaoblonga) seed mucilage (QSM). The intrinsic phytomolecules were utilized as effective reducing agent for the gold ions under ultrasonic conditions. They also enabled the Au NPs to stabilize inherently by capping or encapsulation. The structure of the Au NPs/QSM bio-nanocomposite was analyzed using a range of physicochemical techniques, such as elemental mapping, TEM, FE-SEM, UV-Vis spectroscopy, EDS, and ICP. In medicinal therapeutics sector on human health the cancer treatment assumes an important segment. Furthermore, the material’s biological activity was assessed by examining its antioxidant and cytotoxic characteristics against cell lines of prostate carcinoma. DPPH radical scavenging experiments were used to evaluate the antioxidant potential of Au NPs/QSM, and the resulting IC₅₀ was determined to be 138.1 µg/mL.IC₅₀index of the Au NPs/QSM against PC3, NCI-H660, and LNCaP cell lines were evaluated as 253, 271 and 195 µg/mL, respectively. Au NPs/QSM was found to cause a dose-dependent reduction in the viability of a malignant prostate cell line. The antioxidant properties of recent nanoparticles appear to be the cause of their anti-human prostate carcinoma activity.

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榅桲籽粘液介导的金纳米粒子生物合成：抗前列腺癌和抗氧化特性分析

在此，我们设计了一种通过从榅桲（Cydoniaoblonga）种子粘液（QSM）中提取的天然生物大分子介导的生物制造金纳米粒子的绿色方案。在超声波条件下，固有的植物大分子被用作金离子的有效还原剂。这些植物大分子还能通过封盖或封装使 Au NPs 固有地稳定下来。利用一系列理化技术，如元素图谱、TEM、FE-SEM、UV-Vis 光谱、EDS 和 ICP，分析了 Au NPs/QSM 生物纳米复合材料的结构。在人类健康的药物治疗领域，癌症治疗占有重要地位。此外，还通过研究该材料对前列腺癌细胞系的抗氧化性和细胞毒性特性，对其生物活性进行了评估。利用 DPPH 自由基清除实验评估了 Au NPs/QSM 的抗氧化潜力，得出的 IC50 值为 138.1 µg/mL。Au NPs/QSM 对 PC3、NCI-H660 和 LNCaP 细胞系的 IC50 指数分别为 253、271 和 195 µg/mL。研究发现，Au NPs/QSM 可导致恶性前列腺细胞系的存活率呈剂量依赖性下降。近期纳米粒子的抗氧化特性似乎是它们具有抗人类前列腺癌活性的原因。

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来源期刊

Journal of Polymers and the Environment 工程技术-高分子科学

CiteScore

9.50

自引率

7.50%

发文量

297

审稿时长

9 months

期刊介绍： The Journal of Polymers and the Environment fills the need for an international forum in this diverse and rapidly expanding field. The journal serves a crucial role for the publication of information from a wide range of disciplines and is a central outlet for the publication of high-quality peer-reviewed original papers, review articles and short communications. The journal is intentionally interdisciplinary in regard to contributions and covers the following subjects - polymers, environmentally degradable polymers, and degradation pathways: biological, photochemical, oxidative and hydrolytic; new environmental materials: derived by chemical and biosynthetic routes; environmental blends and composites; developments in processing and reactive processing of environmental polymers; characterization of environmental materials: mechanical, physical, thermal, rheological, morphological, and others; recyclable polymers and plastics recycling environmental testing: in-laboratory simulations, outdoor exposures, and standardization of methodologies; environmental fate: end products and intermediates of biodegradation; microbiology and enzymology of polymer biodegradation; solid-waste management and public legislation specific to environmental polymers; and other related topics.