Unveiling Cuproptosis: Mechanistic insights, roles, and leading advances in oncology

IF 9.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-09-12 DOI:10.1016/j.bbcan.2024.189180
Limei Zhang , Aihui Xie , Jingxian Ma , Huilin Liu , Changchun Zeng
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Abstract

Copper, a vital micronutrient, performs essential functions in numerous biological settings. Its disrupted metabolism is implicated in both the initiation of tumors and therapeutic interventions for cancer, underscoring the critical necessity of preserving copper homeostasis. Cuproptosis, a regulated cell death (RCD) modulated by copper, is activated in response to elevated copper concentrations, prompting an investigation into its implication in oncogenesis. Within this review, an exploration is conducted into copper dynamics and homeostasis maintenance within cells. Furthermore, it delves into the mechanisms underlying cuproptosis and its interplay with signaling pathways implicated in cancer. The potential synergy between cuproptosis and ferroptosis and its impact on tumor immunomodulation is discussed. Additionally, promising avenues for addressing cuproptosis in cancer involve assessing the utility of copper chelators and ionophores. By addressing pressing questions surrounding cuproptosis and outlining its pivotal role in cancer pathogenesis and treatment, this review propounds targeting cuproptosis as a promising frontier in antitumor therapy, potentially revolutionizing cancer treatment strategies.

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揭开杯状突变的神秘面纱:肿瘤学的机制认识、作用和领先进展
铜是一种重要的微量营养元素,在多种生物环境中发挥着重要功能。铜代谢紊乱与肿瘤的诱发和癌症的治疗干预都有关系,这突出表明了保持铜平衡的重要性。铜中毒(Cuproptosis)是一种受铜调节的细胞死亡(RCD),在铜浓度升高时会被激活,这促使人们对其在肿瘤发生中的作用进行研究。本综述探讨了铜在细胞内的动态变化和平衡维持。此外,它还深入探讨了杯突症的内在机制及其与癌症信号通路之间的相互作用。报告还讨论了铜氧化酶和铁氧化酶之间的潜在协同作用及其对肿瘤免疫调节的影响。此外,解决癌症中的铜氧化酶增多问题的可行途径还包括评估铜螯合剂和离子载体的效用。这篇综述探讨了围绕铜氧化酶的迫切问题,概述了它在癌症发病和治疗中的关键作用,认为以铜氧化酶为靶点是抗肿瘤治疗的一个前景广阔的前沿领域,有可能彻底改变癌症治疗策略。
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来源期刊
Biochimica et biophysica acta. Reviews on cancer
Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学
CiteScore
17.20
自引率
0.00%
发文量
138
审稿时长
33 days
期刊介绍: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.
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