Prominent loss of striatal dopamine transporter binding in frontotemporal lobar degeneration with the MAPT N279K mutation present as early as at prodromal stage without parkinsonism
Toji Miyagawa, Cynthia Vernon, Scott A. Przybelski, Paul H. Min, Julie A. Fields, Bradford C. Dickerson, Dennis W. Dickson, Kejal Kantarci, Val J. Lowe, Zbigniew K. Wszolek, Bradley F. Boeve
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引用次数: 0
Abstract
Our research found out, from 123I-FP-CIT SPECT scans of three familial frontotemporal dementia (fFTD) individuals with MAPT N279K mutation and similar autopsy findings of frontotemporal degeneration with severe neuronal loss in the substantia nigra, that prominent decrease of dopamine transporter binding (z-score < −5.0) was present at prodromal fFTD without parkinsonism.
期刊介绍：
Parkinsonism & Related Disorders publishes the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Regular features will include: Review Articles, Point of View articles, Full-length Articles, Short Communications, Case Reports and Letter to the Editor.
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