Podocan unraveled: Understanding its role in tumor proliferation and smooth muscle regulation

IF 6.9 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Biomedicine & Pharmacotherapy Pub Date : 2024-09-13 DOI:10.1016/j.biopha.2024.117416

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Abstract

Podocan, a small leucine-rich repeat protein, is expressed in HIV-associated nephropathy, the cardiovascular system, and smooth muscle. Studies have linked PODN and PODNL to cancers such as osteosarcoma, glioma, and stomach cancer. Research has primarily focused on podocan's role in renal podocytes, injured smooth muscle cells, and various tumor cells. Bioinformatics studies have examined the role of PODN as a biomarker in tumors. Our research summarizes the modulatory role of podocan in smooth muscle and tumor proliferation through its suppression of cell proliferation and promotion of cell differentiation via various signaling pathways, including Wnt/β-catenin, TGF-β, and Akt/mTOR. We aim to provide a comprehensive overview of PODN's involvement in smooth muscle, cardiovascular system, and tumors by integrating current and past research. This review aims to enhance understanding and inform in the diagnosis, prognosis, and treatment of various diseases.

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揭开 Podocan 的神秘面纱：了解其在肿瘤增殖和平滑肌调节中的作用

Podocan 是一种富含亮氨酸的小重复蛋白，在艾滋病毒相关性肾病、心血管系统和平滑肌中均有表达。研究表明，PODN 和 PODNL 与骨肉瘤、胶质瘤和胃癌等癌症有关。研究主要集中于 podocan 在肾脏荚膜细胞、受伤的平滑肌细胞和各种肿瘤细胞中的作用。生物信息学研究探讨了 PODN 在肿瘤中作为生物标记物的作用。我们的研究总结了 podocan 通过各种信号通路（包括 Wnt/β-catenin、TGF-β 和 Akt/mTOR）抑制细胞增殖和促进细胞分化，在平滑肌和肿瘤增殖中的调节作用。我们旨在通过整合当前和过去的研究，全面概述 PODN 在平滑肌、心血管系统和肿瘤中的参与。这篇综述旨在加深人们对各种疾病的理解，并为诊断、预后和治疗提供参考。

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来源期刊

Biomedicine & Pharmacotherapy 医学-药学

CiteScore

11.90

自引率

2.70%

发文量

1621

审稿时长

48 days

期刊介绍： Biomedicine & Pharmacotherapy stands as a multidisciplinary journal, presenting a spectrum of original research reports, reviews, and communications in the realms of clinical and basic medicine, as well as pharmacology. The journal spans various fields, including Cancer, Nutriceutics, Neurodegenerative, Cardiac, and Infectious Diseases.