Hyperactivity and altered functional connectivity of the ventral striatum in schizophrenia compared with bipolar disorder: A resting state fMRI study

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY Psychiatry Research: Neuroimaging Pub Date : 2024-08-30 DOI:10.1016/j.pscychresns.2024.111881

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Abstract

Background

Schizophrenia patients frequently present with structural and functional abnormalities of the ventral striatum (VS).

Methods

we examined basal activation state and functional connectivity (FC) in four subregions of the bilateral ventral striatum: left inferior ventral striatum (VSi_L), left superior ventral striatum(VSs_L), right inferior ventral striatum(VSi_R), and right superior ventral striatum(VSs_R). Resting-state functional magnetic resonance images were obtained from 62 schizophrenia patients (SCH), 57 bipolar disorder (BD) patients, and 26 healthy controls (HCs).

Results

The schizophrenia group exhibited greater fALFF in bilateral VS subregions compared to BD and HC groups as well as greater FC between the bilateral VSi and multiple brain regions, including the thalamus, putamen, posterior cingulate gyrus (PCC), frontal cortex and caudate. Moreover, the fALFF values of the bilateral ventral striatum were positively correlated with the severity of positive symptoms. We also found the functional connectivity between the bilateral inferior ventral striatum and some brain regions aforementioned were positively correlated with the severity of negative symptoms.

Conclusion

These findings confirm a crucial contribution of ventral striatum dysfunction, especially of the bilateral VSi in schizophrenia. Functionally dissociated regions of the ventral striatum are differentially disturbed in schizophrenia.

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与双相情感障碍相比，精神分裂症患者腹侧纹状体的过度活跃和功能连接发生了改变：静息状态 fMRI 研究

背景精神分裂症患者经常出现腹侧纹状体（VS）结构和功能异常。方法我们研究了双侧腹侧纹状体四个亚区的基础激活状态和功能连接（FC）：左下腹侧纹状体（VSi_L）、左上腹侧纹状体（VSs_L）、右下腹侧纹状体（VSi_R）和右上腹侧纹状体（VSs_R）。62 名精神分裂症患者（SCH）、57 名双相情感障碍患者（BD）和 26 名健康对照组（HC）获得了静息态功能磁共振图像。结果与 BD 组和 HC 组相比，精神分裂症组的双侧 VS 亚区的 fALFF 更大，双侧 VSi 与多个脑区（包括丘脑、丘脑、扣带后回、额叶皮层和尾状核）之间的 FC 更大。此外，双侧腹侧纹状体的 fALFF 值与阳性症状的严重程度呈正相关。我们还发现，双侧腹侧纹状体下部与上述一些脑区之间的功能连接与阴性症状的严重程度呈正相关。腹侧纹状体的功能分离区在精神分裂症中受到不同程度的干扰。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatry Research: Neuroimaging 医学-精神病学

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

22.5 weeks

期刊介绍： The Neuroimaging section of Psychiatry Research publishes manuscripts on positron emission tomography, magnetic resonance imaging, computerized electroencephalographic topography, regional cerebral blood flow, computed tomography, magnetoencephalography, autoradiography, post-mortem regional analyses, and other imaging techniques. Reports concerning results in psychiatric disorders, dementias, and the effects of behaviorial tasks and pharmacological treatments are featured. We also invite manuscripts on the methods of obtaining images and computer processing of the images themselves. Selected case reports are also published.