Study of pediatric invasive pneumococcal disease in the 13-pneumococcal conjugated vaccine era

IF 2.1 4区医学 Q3 INFECTIOUS DISEASES Diagnostic microbiology and infectious disease Pub Date : 2024-09-07 DOI:10.1016/j.diagmicrobio.2024.116532

Marta Garrido-Jareño , Francisco Javier Roig-Sena , Elvira Pérez-Pérez , Ana Gil-Brusola , José Luis López-Hontangas , Eulogio Valentín-Gómez , Antonio Pineda-Lucena , Javier Pemán

{"title":"Study of pediatric invasive pneumococcal disease in the 13-pneumococcal conjugated vaccine era","authors":"Marta Garrido-Jareño , Francisco Javier Roig-Sena , Elvira Pérez-Pérez , Ana Gil-Brusola , José Luis López-Hontangas , Eulogio Valentín-Gómez , Antonio Pineda-Lucena , Javier Pemán","doi":"10.1016/j.diagmicrobio.2024.116532","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Invasive pneumococcal disease (IPD) remains a significant concern among children under 5, despite vaccination efforts. This study assessed IPD prevalence and associated risks in pediatric population.</p></div><div><h3>Methods</h3><p>An observational, retrospective, multicenter study in Comunidad Valenciana, Spain, of IPD cases in children under 13 from January 2012 to September 2022. Data from the CV Microbiology Surveillance Network (RedMIVA) and medical records were reviewed.</p></div><div><h3>Results</h3><p>A total of 379 IPD cases in 377 patients were analyzed, predominantly males (54.11 %) under 5 (81.17 %). PCV13 vaccination notably reduced PCV13-serotypes IPD (p=0.0002), except serotype 3. Pneumonia was common, with half having underlying conditions (50.40 %). Worse outcomes occurred in patients with neurological disorders (ANOVA, p=0.57). Vaccine failures often involved underlying conditions (63 %) and serotypes 3 and 19A. Immunodeficiencies may relate to recurrent IPD, but evidence is limited.</p></div><div><h3>Conclusion</h3><p>Despite vaccination, IPD still impacts children, influenced by immunological status, affecting severity and mortality.</p></div>","PeriodicalId":11329,"journal":{"name":"Diagnostic microbiology and infectious disease","volume":"110 4","pages":"Article 116532"},"PeriodicalIF":2.1000,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diagnostic microbiology and infectious disease","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0732889324003572","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Invasive pneumococcal disease (IPD) remains a significant concern among children under 5, despite vaccination efforts. This study assessed IPD prevalence and associated risks in pediatric population.

Methods

An observational, retrospective, multicenter study in Comunidad Valenciana, Spain, of IPD cases in children under 13 from January 2012 to September 2022. Data from the CV Microbiology Surveillance Network (RedMIVA) and medical records were reviewed.

Results

A total of 379 IPD cases in 377 patients were analyzed, predominantly males (54.11 %) under 5 (81.17 %). PCV13 vaccination notably reduced PCV13-serotypes IPD (p=0.0002), except serotype 3. Pneumonia was common, with half having underlying conditions (50.40 %). Worse outcomes occurred in patients with neurological disorders (ANOVA, p=0.57). Vaccine failures often involved underlying conditions (63 %) and serotypes 3 and 19A. Immunodeficiencies may relate to recurrent IPD, but evidence is limited.

Conclusion

Despite vaccination, IPD still impacts children, influenced by immunological status, affecting severity and mortality.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

13 型肺炎球菌结合疫苗时代的小儿侵袭性肺炎球菌疾病研究

背景尽管接种了疫苗，但侵袭性肺炎球菌疾病（IPD）在 5 岁以下儿童中仍是一个令人严重关切的问题。本研究评估了 IPD 在儿科人群中的流行率和相关风险。方法：一项在西班牙巴伦西亚大区开展的观察性、回顾性、多中心研究，研究对象为 2012 年 1 月至 2022 年 9 月期间 13 岁以下儿童中的 IPD 病例。结果共分析了377名患者中的379例IPD病例，主要为5岁以下男性（54.11%）（81.17%）。接种 PCV13 疫苗显著减少了 PCV13 血清型 IPD（p=0.0002），血清型 3 除外。肺炎很常见，半数患者（50.40%）患有基础疾病。患有神经系统疾病的患者的治疗效果较差（方差分析，p=0.57）。疫苗接种失败通常与潜在疾病（63%）以及血清型 3 和 19A 有关。免疫缺陷可能与 IPD 复发有关，但证据有限。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.