Breast Tumor Cell Survival and Morphology in a Brain-like Extracellular Matrix Depends on Matrix Composition and Mechanical Properties (Adv. Biology 9/2024)

IF 3.2 3区生物学 Q3 MATERIALS SCIENCE, BIOMATERIALS Advanced biology Pub Date : 2024-09-15 DOI:10.1002/adbi.202470091

Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Selma J. Padilla Padilla, Nicoletta Murenu, Philipp Stahlhut, Gregor Lang, Zan Lamberger, Jeanette Weigelt, Natascha Schaefer, Jörg Tessmar, Pamela L. Strissel, Torsten Blunk, Silvia Budday, Reiner Strick, Carmen Villmann

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Abstract

Breast Tumor Cells

Triple-negative breast cancer (TNBC) is the most invasive type of breast cancer with a high risk of brain metastasis. In article number 2400184, Carmen Villmann and co-workers systematically set up a 3D cellular system to study TNBC in a biomimetic brain surrounding in terms of cell–cell and cell–matrix interactions. 3D disease model for breast tumor cells (green) attached to collagen (red, confocal image) grown in thiolated hyaluronic acid-based hydrogel (background image black). Icons represent MEW PCL scaffolds, PEGAcr crosslinker, different extracellular matrix (ECM) proteins (collagen, fibronectin, laminin). ECM supplementation is the key regulator of cellular morphology behaviour and survival. The original confocal image was modified using an art filter.

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乳腺肿瘤细胞在类脑细胞外基质中的存活和形态取决于基质成分和机械特性（生物学进展 9/2024）

乳腺肿瘤细胞三阴性乳腺癌（TNBC）是侵袭性最强的乳腺癌类型，脑转移风险很高。在编号为 2400184 的文章中，Carmen Villmann 及其合作者系统地建立了一个三维细胞系统，从细胞-细胞和细胞-基质相互作用的角度研究了在生物仿真大脑周围的 TNBC。乳腺肿瘤细胞（绿色）附着在生长在硫醇化透明质酸水凝胶（背景图片黑色）中的胶原蛋白（红色，共聚焦图像）上的三维疾病模型。图标代表 MEW PCL 支架、PEGAcr 交联剂、不同的细胞外基质（ECM）蛋白（胶原蛋白、纤连蛋白、层粘连蛋白）。ECM 补充是细胞形态行为和存活的关键调节因子。使用艺术滤镜对原始共焦图像进行修改。

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