Pathological Spontaneous Activity in Different Thoracic Paraspinal Muscles in Amyotrophic Lateral Sclerosis

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY Acta Neurologica Scandinavica Pub Date : 2024-09-16 DOI:10.1155/2024/7102913

Yuting Ren, Na Chen, Kang Zhang, Bin Chen, Songtao Niu, Xingao Wang, Fan Jian, Zaiqiang Zhang, Hua Pan

{"title":"Pathological Spontaneous Activity in Different Thoracic Paraspinal Muscles in Amyotrophic Lateral Sclerosis","authors":"Yuting Ren, Na Chen, Kang Zhang, Bin Chen, Songtao Niu, Xingao Wang, Fan Jian, Zaiqiang Zhang, Hua Pan","doi":"10.1155/2024/7102913","DOIUrl":null,"url":null,"abstract":"Objective: The aim of our study was to compare the clinical value of pathological spontaneous activity (PSA) in different thoracic paraspinal muscles (TPMs) in amyotrophic lateral sclerosis (ALS).Methods: A total of 116 ALS patients were retrospectively analyzed over 31 ± 8 months concerning the occurrence of PSA in T9–T11 TPM. The occurrence of PSA was correlated with pulmonary function and clinical disability.Results: The positive sharp wave (PSW) potentials were more frequently observed than fibrillation (fib) in T9–T11 segments. The PSA positive frequency of bulbar-onset ALS (B-ALS) is less than upper limb-onset ALS (U-ALS) and lower limb-onset ALS (L-ALS) at the levels of T10 and T11 TPM (p = 0.050, p = 0.001). The fibs/PSWs in TPM indicated high sensitivity and negative predictive value for forced vital capacity (FVC) < 80%. Linear correlation analysis indicated that PSA of TPM was associated with pulmonary ventilation function (PVF). Associations also exist between clinical parameters and PVF as well as the disease severity.Conclusions: The occurrence of T9-TPM fibs/PSWs was correlated with clinical disability and is extremely helpful in implying an involvement of PVF. The T9-TPM typically provided a good practical indicator for comprehensive disease evaluation, which was irrelevant to the site of onset.","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":null,"pages":null},"PeriodicalIF":2.9000,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/7102913","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Neurologica Scandinavica","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1155/2024/7102913","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: The aim of our study was to compare the clinical value of pathological spontaneous activity (PSA) in different thoracic paraspinal muscles (TPMs) in amyotrophic lateral sclerosis (ALS).

Methods: A total of 116 ALS patients were retrospectively analyzed over 31 ± 8 months concerning the occurrence of PSA in T9–T11 TPM. The occurrence of PSA was correlated with pulmonary function and clinical disability.

Results: The positive sharp wave (PSW) potentials were more frequently observed than fibrillation (fib) in T9–T11 segments. The PSA positive frequency of bulbar-onset ALS (B-ALS) is less than upper limb-onset ALS (U-ALS) and lower limb-onset ALS (L-ALS) at the levels of T10 and T11 TPM (p = 0.050, p = 0.001). The fibs/PSWs in TPM indicated high sensitivity and negative predictive value for forced vital capacity (FVC) < 80%. Linear correlation analysis indicated that PSA of TPM was associated with pulmonary ventilation function (PVF). Associations also exist between clinical parameters and PVF as well as the disease severity.

Conclusions: The occurrence of T9-TPM fibs/PSWs was correlated with clinical disability and is extremely helpful in implying an involvement of PVF. The T9-TPM typically provided a good practical indicator for comprehensive disease evaluation, which was irrelevant to the site of onset.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

肌萎缩性脊髓侧索硬化症患者不同胸椎旁侧肌肉的病理自发活动

研究目的我们的研究旨在比较肌萎缩性脊髓侧索硬化症（ALS）患者不同胸椎旁肌（TPM）病理自发活动（PSA）的临床价值：方法：对116例ALS患者31±8个月的T9-T11 TPM PSA发生情况进行回顾性分析。PSA的发生与肺功能和临床残疾相关：结果：在T9-T11节段观察到的尖波（PSW）正电位比颤动（fib）更频繁。在 T10 和 T11 TPM 水平，球部发病 ALS（B-ALS）的 PSA 阳性频率低于上肢发病 ALS（U-ALS）和下肢发病 ALS（L-ALS）（p = 0.050，p = 0.001）。TPM 中的纤维/PSWs 对强迫生命容量（FVC）的灵敏度和阴性预测值均较高，可达 80%。线性相关分析表明，TPM 的 PSA 与肺通气功能（PVF）相关。临床参数和肺通气功能以及疾病严重程度之间也存在关联：结论：T9-TPM 纤维/PSW 的出现与临床残疾相关，对暗示肺通气功能受累大有帮助。T9-TPM 通常为综合疾病评估提供了一个很好的实用指标，与发病部位无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Acta Neurologica Scandinavica 医学-临床神经学

CiteScore

6.70

自引率

2.90%

发文量

161

审稿时长

4-8 weeks

期刊介绍： Acta Neurologica Scandinavica aims to publish manuscripts of a high scientific quality representing original clinical, diagnostic or experimental work in neuroscience. The journal''s scope is to act as an international forum for the dissemination of information advancing the science or practice of this subject area. Papers in English will be welcomed, especially those which bring new knowledge and observations from the application of therapies or techniques in the combating of a broad spectrum of neurological disease and neurodegenerative disorders. Relevant articles on the basic neurosciences will be published where they extend present understanding of such disorders. Priority will be given to review of topical subjects. Papers requiring rapid publication because of their significance and timeliness will be included as ''Clinical commentaries'' not exceeding two printed pages, as will ''Clinical commentaries'' of sufficient general interest. Debate within the speciality is encouraged in the form of ''Letters to the editor''. All submitted manuscripts falling within the overall scope of the journal will be assessed by suitably qualified referees.