Distinct medial amygdala oxytocin receptor neurons projections respectively control consolation or aggression in male mandarin voles

IF 14.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Nature Communications Pub Date : 2024-09-17 DOI:10.1038/s41467-024-51652-8

Yishan Qu, Lizi Zhang, Wenjuan Hou, Limin Liu, Jing Liu, Lu Li, Xing Guo, Yin Li, Caihong Huang, Zhixiong He, Fadao Tai

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Abstract

The individuals often show consolation to distressed companions or show aggression to the intruders. The circuit mechanisms underlying switching between consolation and aggression remain unclear. In the present study, using male mandarin voles, we identified that two distinct subtypes of oxytocin receptor (OXTR) neurons in the medial amygdala (MeA) projecting to the anterior insula (AI) and ventrolateral aspect of ventromedial hypothalamus (VMHvl) response differently to stressed siblings or unfamiliar intruders using c-Fos or calcium recording. Oxytocin release and activities of PVN neurons projecting to MeA increased upon consoling and attacking. OXTR antagonist injection to the MeA reduced consoling and attacking. Apoptosis, optogenetic or pharmacogenetic manipulation of these two populations of neurons altered behavioral responses to these two social stimuli respectively. Here, we show that two subtypes of OXTR neurons in the MeA projecting to the AI or VMHvl causally control consolation or aggression that may underlie switch between consolation and aggression.

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不同的杏仁核内侧催产素受体神经元投射分别控制雄性鸳鸯田鼠的安慰或攻击行为

这些个体经常会对痛苦的同伴表示安慰，或者对入侵者表现出攻击性。在安慰和攻击之间切换的电路机制尚不清楚。在本研究中，我们以雄性鸳鸯田鼠为研究对象，利用c-Fos或钙离子记录发现，内侧杏仁核（MeA）中两种不同亚型的催产素受体（OXTR）神经元投射到前脑岛（AI）和腹外侧下丘脑（VMHvl），对受压的兄弟姐妹或陌生的入侵者做出不同的反应。在安慰和攻击时，催产素的释放和投射到 MeA 的 PVN 神经元的活动都会增加。向MeA注射OXTR拮抗剂可减少安慰和攻击行为。对这两种神经元群进行凋亡、光遗传学或药物遗传学操作可分别改变对这两种社会刺激的行为反应。在这里，我们证明了在MeA中投射到AI或VMHvl的两种亚型OXTR神经元因果地控制着安慰或攻击，这可能是安慰和攻击之间切换的基础。

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来源期刊

Nature Communications Biological Science Disciplines-

CiteScore

24.90

自引率

2.40%

发文量

6928

审稿时长

3.7 months

期刊介绍： Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.