Excellent lubricating hydrogels with rapid photothermal sterilization for medical catheters coating

IF 6.3 1区工程技术 Q1 ENGINEERING, MECHANICAL Friction Pub Date : 2024-09-18 DOI:10.1007/s40544-024-0903-6

Yue Sun, Zhenling Shang, Chenghao Li, Jinglun Guo, Zhuo Chen, Nan Zhao, Guoqiang Liu, Feng Zhou, Weimin Liu

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Abstract

Bacterial infection and tissue damage caused by friction are two major threats to patients’ health in medical catheter implantation. Hydrogels with antibacterial and lubrication effects are competitive candidates for catheter coating materials. Photothermal therapy (PTT) is a highly efficient bactericidal method. Here, a composite hydrogel containing MXene nanosheets and hydrophilic 3-sulfopropyl methacrylate potassium salt (SPMK) is reported, which is synthesized through the one-pot method and heat-initiated polymerization. The hydrogel shows excellent antibacterial performance against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) in 3 min in the air or 20 min in the water environment under near-infrared light (NIR; 808 nm) irradiation. The friction coefficient of the hydrogel is about 0.11, which is 48% lower than that without SPMK. The rapid photothermal sterilization is attributed to the outstanding antibacterial ability and thermal effect of photoactivated MXene. The ultra-low friction is the result of the hydration lubrication mechanism. This study provides a potential strategy for the surface coatings of biomedical catheters, which enables rapid sterilization and extremely low interface resistance between catheters and biological tissues.

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用于医用导管涂层的具有快速光热灭菌功能的优质润滑水凝胶

细菌感染和摩擦造成的组织损伤是植入医用导管时对患者健康的两大威胁。具有抗菌和润滑效果的水凝胶是导管涂层材料的理想候选材料。光热疗法（PTT）是一种高效的杀菌方法。本文报道了一种含有 MXene 纳米片和亲水性 3-甲基丙烯酸磺丙基钾盐（SPMK）的复合水凝胶，该水凝胶是通过一锅法和热引发聚合合成的。在近红外线（NIR；808 nm）照射下，该水凝胶在空气中 3 分钟或水环境中 20 分钟内对大肠杆菌（E. coli）和金黄色葡萄球菌（S. aureus）具有优异的抗菌性能。水凝胶的摩擦系数约为 0.11，比不含 SPMK 的水凝胶低 48%。快速光热杀菌的原因是光活化 MXene 具有出色的抗菌能力和热效应。超低摩擦力是水合润滑机制的结果。这项研究为生物医学导管的表面涂层提供了一种潜在的策略，它可以实现快速灭菌以及导管与生物组织之间极低的界面阻力。

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来源期刊

Friction Engineering-Mechanical Engineering

CiteScore

12.90

自引率

13.20%

发文量

324

审稿时长

13 weeks

期刊介绍： Friction is a peer-reviewed international journal for the publication of theoretical and experimental research works related to the friction, lubrication and wear. Original, high quality research papers and review articles on all aspects of tribology are welcome, including, but are not limited to, a variety of topics, such as: Friction: Origin of friction, Friction theories, New phenomena of friction, Nano-friction, Ultra-low friction, Molecular friction, Ultra-high friction, Friction at high speed, Friction at high temperature or low temperature, Friction at solid/liquid interfaces, Bio-friction, Adhesion, etc. Lubrication: Superlubricity, Green lubricants, Nano-lubrication, Boundary lubrication, Thin film lubrication, Elastohydrodynamic lubrication, Mixed lubrication, New lubricants, New additives, Gas lubrication, Solid lubrication, etc. Wear: Wear materials, Wear mechanism, Wear models, Wear in severe conditions, Wear measurement, Wear monitoring, etc. Surface Engineering: Surface texturing, Molecular films, Surface coatings, Surface modification, Bionic surfaces, etc. Basic Sciences: Tribology system, Principles of tribology, Thermodynamics of tribo-systems, Micro-fluidics, Thermal stability of tribo-systems, etc. Friction is an open access journal. It is published quarterly by Tsinghua University Press and Springer, and sponsored by the State Key Laboratory of Tribology (TsinghuaUniversity) and the Tribology Institute of Chinese Mechanical Engineering Society.