One Pot Synthesis of C3-Sulfurized Imidazolo [1,2-a] Pyridines

IF 3.3 2区 化学 Q1 CHEMISTRY, ORGANIC The Journal of Organic Chemistry Pub Date : 2024-09-18 DOI:10.1021/acs.joc.4c01524
Ya-Dan Zhang, Zhi-Peng Guan, Zhi-Bing Dong
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Abstract

A facile and efficient annulation strategy was developed from easily accessible a-bromoketones, aminopyridines and benzazol, which afforded a series of imidazole [1,2-a]pyridine sulfides in moderate to good yields. The reaction involves the formation of C–N/C–S bond with the advantages of easy operation and wide substrates scope.

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一锅合成 C3 硫化咪唑并 [1,2-a] 吡啶
研究人员从容易获得的 a-溴酮类化合物、氨基吡啶类化合物和苯并唑类化合物出发,开发出一种简便高效的环化反应策略,以中等至良好的产率获得了一系列咪唑 [1,2-a]啶硫化物。该反应涉及 C-N/C-S 键的形成,具有操作简便、底物范围广等优点。
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来源期刊
The Journal of Organic Chemistry
The Journal of Organic Chemistry 化学-有机化学
CiteScore
6.20
自引率
11.10%
发文量
1467
审稿时长
2 months
期刊介绍: The Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.
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