Characterization of a natural model of adult mice with different rate of aging

IF 5.3 3区医学 Q2 CELL BIOLOGY Mechanisms of Ageing and Development Pub Date : 2024-09-14 DOI:10.1016/j.mad.2024.111991

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Abstract

Aging is a heterogeneous process, so individuals of the same age may be aging at a different rate. A natural model of premature aging in mice have been proposed based on the poor response to the T-maze. Those that take longer to cross the intersection are known as Prematurely Aging Mice (PAM), while those that show an exceptional response are known as Exceptional non-PAM (E-NPAM), being the rest non-PAM (NPAM). Although many aspects of PAM and E-NPAM have been described, some aspects of their brain aging have not been studied. Similarly, it is known that PAM, NPAM and E-NPAM show a different rate of aging and longevity, but the differences between these three groups in behavior, immune function and oxidative-inflammatory state are unknown. The present study aims to deepen the study of brain aging in PAM and E-NPAM, and to study the differences in behavior, immunity, and oxidative-inflammatory state of peritoneal leukocytes between PAM, NPAM and E-NPAM. Results show deteriorated brains in PAM. Moreover, NPAM show an oxidative state similar to E-NPAM, an anxiety similar to PAM, and an intermediate immunity and lifespan between PAM and E-NPAM. In conclusion, immune function seems to be more associated with the longevity achieved.

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不同衰老速度成年小鼠自然模型的特征

衰老是一个异质性过程，因此同龄人的衰老速度可能不同。有人根据小鼠对 T 型迷宫的不良反应，提出了一种自然的小鼠早衰模型。那些需要较长时间才能通过十字路口的小鼠被称为早衰小鼠（PAM），而那些表现出特殊反应的小鼠被称为特殊非早衰小鼠（E-NPAM），即其余非早衰小鼠（NPAM）。虽然人们已经对 PAM 和 E-NPAM 的许多方面进行了描述，但对它们大脑衰老的某些方面还没有进行研究。同样，已知 PAM、NPAM 和 E-NPAM 的衰老速度和寿命不同，但这三类人在行为、免疫功能和氧化-炎症状态方面的差异尚不清楚。本研究旨在深化对 PAM 和 E-NPAM 脑衰老的研究，并研究 PAM、NPAM 和 E-NPAM 在行为、免疫和腹腔白细胞氧化炎症状态方面的差异。结果显示，PAM 的大脑功能退化。此外，NPAM 的氧化状态与 E-NPAM 相似，焦虑与 PAM 相似，免疫力和寿命介于 PAM 和 E-NPAM 之间。总之，免疫功能似乎与所达到的寿命更相关。

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来源期刊

Mechanisms of Ageing and Development 医学-老年医学

CiteScore

11.10

自引率

1.90%

发文量

审稿时长

32 days

期刊介绍： Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms. Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.

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