Cover Feature: Synthesis and Thermodynamic Evaluation of Sialyl-Tn MUC1 Glycopeptides Binding to Macrophage Galactose-Type Lectin (ChemBioChem 18/2024)

IF 2.8 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY ChemBioChem Pub Date : 2024-09-16 DOI:10.1002/cbic.202481804
Ramya Ayyalasomayajula, Ivet Boneva, David Ormaza, Andrew Whyte Jr., Kamran Farook, Zachary Gorlin, Evelyn Yancey, Sabine André, Herbert Kaltner, Maré Cudic
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Abstract

Isothermal titration calorimetry (ITC) analysis of the binding of hMGL to Tn and sialyl-Tn MUC1 glycopeptides revealed a dynamic process in which lectin molecules bind to carbohydrate ligands and jump from ligand to ligand along the glycopeptides’ backbone. More details can be found in article 10.1002/cbic.202400391 by Maré Cudic and co-workers.

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封面专题:与巨噬细胞半乳糖型凝集素结合的 Sialyl-Tn MUC1 糖肽的合成与热力学评估(ChemBioChem 18/2024)
对 hMGL 与 Tn 和 sialyl-Tn MUC1 糖肽结合的等温滴定量热法(ITC)分析表明了一个动态过程,在这个过程中,凝集素分子与碳水化合物配体结合,并沿着糖肽骨架从一个配体跳到另一个配体。更多详情请见 Maré Cudic 及其合作者撰写的文章 10.1002/cbic.202400391。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ChemBioChem
ChemBioChem 生物-生化与分子生物学
CiteScore
6.10
自引率
3.10%
发文量
407
审稿时长
1 months
期刊介绍: ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).
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